Evidence map›Paper›PMID 27535644›Full record

ReviewDiabetes & metabolism journal2016

The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Kimberley L Way, Daniel A Hackett, Michael K Baker, Nathan A Johnson

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes & metabolism journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03335930 (Tri-Service General Hospital, National Defense Medical Center), which is not on this map. Cited by 105 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 14 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03335930 nacompletednot on this map

Tri-Service General Hospital, National Defense Medical Center

TypeinterventionalSponsorTri-Service General Hospital (TSGH)Ran2009 to 2009Enrolled13ConditionsType 2 Diabetes MellitusArmsa 12-week moderate-intensity exercise training
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 14 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  5. Predictor factors of uncontrolled diabetes.BMC endocrine disorders · 2025
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kimberley L WayUniversity of Sydney Faculty of Health Sciences, Lidcombe, Australia.ORCID http://orcid.org/0000-0002-1999-2498
Daniel A HackettUniversity of Sydney Faculty of Health Sciences, Lidcombe, Australia.
Michael K BakerBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders, Sydney Medical School University of Sydney, Camperdown, Australia.
Nathan A JohnsonUniversity of Sydney Faculty of Health Sciences, Lidcombe, Australia.ORCID http://orcid.org/0000-0002-3874-7092
The University of Sydney · AUBankstown Lidcombe Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus (T2DM) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size (ES) for the effect of exercise on insulin sensitivity (ES, -0.588; 95% confidence interval [CI], -0.816 to -0.359; P<0.001). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise (ES, -0.702; 95% CI, -1.392 to -0.012; P=0.046); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session (ES, -0.890; 95% CI, -1.675 to -0.105; P=0.026). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session.

Indexed as

Aerobic trainingGlucose tolerance testHyperinsulinaemic euglycaemic clampInsulin resistanceResistance training

Identifiers

PMID27535644
PMCPMC4995180
OpenAlexW2517945165

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.