Evidence map›Paper›PMID 27535569›Full record

ReviewThe journal of physiological sciences : JPS2017

The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology.

Keiko Ikeda, Kiyoshi Kawakami, Hiroshi Onimaru, Yasumasa Okada, Shigefumi Yokota, Naohiro Koshiya, Yoshitaka Oku, Makito Iizuka, Hidehiko Koizumi

Open access · goldAbstract readReview
In one paragraph

Review in The journal of physiological sciences : JPS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 149 citations in OpenAlex.

  1. Trial
  2. Effects of opioids and stimulants on the respiratory system.European respiratory review : an official journal of the European Respiratory Society · 2026
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  20. Respiratory Depression Associated with Opioids: A Narrative Review.Current treatment options in oncology · 2024
    Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Keiko IkedaDivision of Biology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan. kiikeda@hyo-med.ac.jp.
Kiyoshi KawakamiDivision of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, 329-0498, Japan.
Hiroshi OnimaruDepartment of Physiology, Showa University School of Medicine, Shinagawa, Tokyo, 142-8555, Japan. oni@med.showa-u.ac.jp.
Yasumasa OkadaClinical Research Center, Murayama Medical Center, Musashimurayama, Tokyo, 208-0011, Japan. yasumasaokada@1979.jukuin.keio.ac.jp.
Shigefumi YokotaDepartment of Anatomy and Morphological Neuroscience, Shimane University School of Medicine, Izumo, Shimane, 693-8501, Japan.
Naohiro KoshiyaCellular and Systems Neurobiology Section, NINDS, NIH, Bethesda, MD, 20892, USA. nk@mail.nih.gov.
Yoshitaka OkuDepartment of Physiology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan. yoku@hyo-med.ac.jp.
Makito IizukaDepartment of Physiology, Showa University School of Medicine, Shinagawa, Tokyo, 142-8555, Japan. iizukam@med.showa-u.ac.jp.
Hidehiko KoizumiCellular and Systems Neurobiology Section, NINDS, NIH, Bethesda, MD, 20892, USA.
Hyogo Medical University · JPShowa University · JPJichi Medical University · JPMurayama Medical Center · JPNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USShimane University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory activities are produced by medullary respiratory rhythm generators and are modulated from various sites in the lower brainstem, and which are then output as motor activities through premotor efferent networks in the brainstem and spinal cord. Over the past few decades, new knowledge has been accumulated on the anatomical and physiological mechanisms underlying the generation and regulation of respiratory rhythm. In this review, we focus on the recent findings and attempt to elucidate the anatomical and functional mechanisms underlying respiratory control in the lower brainstem and spinal cord.

Indexed as

RespirationAnimalsBrain StemHumansMedulla OblongataNeuronsRespiratory CenterSpinal CordMedullaParafacial respiratory group (pFRG)PonsPre-Bötzinger complex (preBötC)Respiratory rhythmSpinal cord

Identifiers

PMID27535569
PMCPMC5368202
OpenAlexW2514604537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.