Evidence map›Paper›PMID 27535485›Full record

ReviewAdvanced drug delivery reviews2017

Self-assembling peptide-based building blocks in medical applications.

Handan Acar, Samanvaya Srivastava, Eun Ji Chung, Mathew R Schnorenberg, John C Barrett, James L LaBelle, Matthew Tirrell

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed.

  1. Article
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  3. Review
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  8. Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. The effects of self-assembling peptide on glial cell activation.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Handan AcarInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: hacar@uchicago.edu.
Samanvaya SrivastavaInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Institute for Molecular Engineering, Argonne National Laboratory, Argonne, IL 60439, USA. Electronic address: samsri@uchicago.edu.
Eun Ji ChungInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Mathew R SchnorenbergInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA; Medical Scientist Training Program, University of Chicago, Chicago, IL 60637, USA. Electronic address: schnorenberg@uchicago.edu.
John C BarrettBiophysical Sciences Graduate Program, University of Chicago, Chicago, IL 60637, USA. Electronic address: jcbarrett@uchicago.edu.
James L LaBelleDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: jlabelle@peds.bsd.uchicago.edu.
Matthew TirrellInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Institute for Molecular Engineering, Argonne National Laboratory, Argonne, IL 60439, USA. Electronic address: mtirrell@uchicago.edu.

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Pathologic BIM Suppression & Pharmacologic BH3 Replacement in B-Cell LymphomaK08CA151450 · NCI · UNIVERSITY OF CHICAGO · PI LABELLE, JAMES LAURENCE · 2011 to 2015
$842k
Multimodal Peptide Amphiphile Micelles for AtherosclerosisK99HL124279 · NHLBI · UNIVERSITY OF CHICAGO · PI CHUNG, EUN JI PAIGE · 2015 to 2016
$180k
NCI NIH HHS K08 CA151450NHLBI NIH HHS K99 HL124279NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

Peptides and peptide-conjugates, comprising natural and synthetic building blocks, are an increasingly popular class of biomaterials. Self-assembled nanostructures based on peptides and peptide-conjugates offer advantages such as precise selectivity and multifunctionality that can address challenges and limitations in the clinic. In this review article, we discuss recent developments in the design and self-assembly of various nanomaterials based on peptides and peptide-conjugates for medical applications, and categorize them into two themes based on the driving forces of molecular self-assembly. First, we present the self-assembled nanostructures driven by the supramolecular interactions between the peptides, with or without the presence of conjugates. The studies where nanoassembly is driven by the interactions between the conjugates of peptide-conjugates are then presented. Particular emphasis is given to in vivo studies focusing on therapeutics, diagnostics, immune modulation and regenerative medicine. Finally, challenges and future perspectives are presented.

Indexed as

AnimalsBiocompatible MaterialsDrug DesignHumansNanostructuresPeptidesRegenerative MedicineBiocompatible MaterialsPeptidesMedicinePeptidePeptide-conjugatesSelf-assemblySupramolecular

Identifiers

PMID27535485
PMCPMC5922461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.