ArticleBrain structure & function2017
Education is associated with sub-regions of the hippocampus and the amygdala vulnerable to neuropathologies of Alzheimer's disease.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Hippocampal sub-regional shape and physical activity in older adults.Hippocampus · 2016Trial
- Causal relationships between hippocampal volumetric traits and the risk of Alzheimer's disease: a Mendelian randomization study.Brain communications · 2025Article
- Effects of educational attainment on comorbidity of pain and depression in Chinese older adults.Heliyon · 2024Article
- Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study.Scientific reports · 2024Article
- The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms.Molecular neurodegeneration · 2024Review
- Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies.Frontiers in neuroscience · 2024Review
- Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis.Brain : a journal of neurology · 2023Article
- Resilience of Neural Cellularity to the Influence of Low Educational Level.Brain sciences · 2023Article
- Piecing it together: atrophy profiles of hippocampal subfields relate to cognitive impairment along the Alzheimer's disease spectrum.Frontiers in aging neuroscience · 2023Article
- Executive function deficits and medial temporal lobe atrophy in late-life depression and Alzheimer's disease: a comparative study.Frontiers in psychiatry · 2023Article
- Novel characterization of the relationship between verbal list-learning outcomes and hippocampal subfields in healthy adults.Human brain mapping · 2021Article
- Prediction of 7-year's conversion from subjective cognitive decline to mild cognitive impairment.Human brain mapping · 2021Article
- Rajyoga meditation induces grey matter volume changes in regions that process reward and happiness.Scientific reports · 2020Article
- Amygdalar and Hippocampal Morphometry Abnormalities in First-Episode Schizophrenia Using Deformation-Based Shape Analysis.Frontiers in psychiatry · 2020Article
- Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults.Neurobiology of aging · 2019Article
- Investigating Individual Pre-trauma Susceptibility to a PTSD-Like Phenotype in Animals.Frontiers in systems neuroscience · 2019Review
- Educational Attainment Moderates the Association Between Hippocampal Volumes and Memory Performances in Healthy Older Adults.Frontiers in aging neuroscience · 2018Article
- A Fully-Automated Subcortical and Ventricular Shape Generation Pipeline Preserving Smoothness and Anatomical Topology.Frontiers in neuroscience · 2018Article
- Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936.Neurobiology of aging · 2017Article
- Alzheimer's Disease in the Latino Community: Intersection of Genetics and Social Determinants of Health.Journal of Alzheimer's disease : JAD · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We evaluated the correlation of educational attainment with structural volume and shape morphometry of the bilateral hippocampi and amygdalae in a sample of 110 non-demented, older adults at elevated sociodemographic risk for cognitive and functional declines. In both men and women, no significant education-volume correlation was detected for either structure. However, when performing shape analysis, we observed regionally specific associations with education after adjusting for age, intracranial volume, and race. By sub-dividing the hippocampus and the amygdala into compatible subregions, we found that education was positively associated with size variations in the CA1 and subiculum subregions of the hippocampus and the basolateral subregion of the amygdala (p < 0.05). In addition, we detected a greater left versus right asymmetric pattern in the shape-education correlation for the hippocampus but not the amygdala. This asymmetric association was largely observed in men versus women. These findings suggest that education in youth may exert direct and indirect influences on brain reserve in regions that are most vulnerable to the neuropathologies of aging, dementia, and specifically, Alzheimer disease.
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