Evidence map›Paper›PMID 27535380›Full record

ArticleMolecular brain2016

Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey.

Qun-Yong Zhou, Katherine J Burton, Matthew L Neal, Yu Qiao, Anumantha G Kanthasamy, Yanjun Sun, Xiangmin Xu, Yuanye Ma, Xiaohan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Qun-Yong ZhouDepartment of Pharmacology, University of California, Irvine, CA, USA. qzhou@uci.edu.
Katherine J BurtonDepartment of Pharmacology, University of California, Irvine, CA, USA.
Matthew L NealDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Yu QiaoDepartment of Neurosurgery, Kunming Medical University Hospital, Yunan, China.
Anumantha G KanthasamyDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Yanjun SunDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA.
Xiangmin XuDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA.
Yuanye MaInstitute of Primate Translational Medicine, Kunming University of Science and Technology, Yunnan, China.
Xiaohan LiDepartment of Pharmacology, University of California, Irvine, CA, USA.
University of California, Irvine · USIowa State University · USKunming Medical University · CNKunming University of Science and Technology · CN

Funding

Inhibitory neuron circuit organization and function in prefrontal cortex.R01MH105427 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLSHANI, PEYMAN, XU, XIANGMIN · 2015 to 2019
$2.3M
Hippocampal inhibitory neuronal circuit organizationR01NS078434 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2012 to 2016
$1.6M
NIMH NIH HHS R01 MH105427NINDS NIH HHS R01 NS078434
6 · The paper itself

Abstract

The temporal organization of activity/rest or sleep/wake rhythms for mammals is regulated by the interaction of light/dark cycle and circadian clocks. The neural and molecular mechanisms that confine the active phase to either day or night period for the diurnal and the nocturnal mammals are unclear. Here we report that prokineticin 2, previously shown as a circadian clock output molecule, is expressed in the intrinsically photosensitive retinal ganglion cells, and the expression of prokineticin 2 in the intrinsically photosensitive retinal ganglion cells is oscillatory in a clock-dependent manner. We further show that the prokineticin 2 signaling is required for the activity and arousal suppression by light in the mouse. Between the nocturnal mouse and the diurnal monkey, a signaling receptor for prokineticin 2 is differentially expressed in the retinorecipient suprachiasmatic nucleus and the superior colliculus, brain projection targets of the intrinsically photosensitive retinal ganglion cells. Blockade with a selective antagonist reveals the respectively inhibitory and stimulatory effect of prokineticin 2 signaling on the arousal levels for the nocturnal mouse and the diurnal monkey. Thus, the mammalian diurnality or nocturnality is likely determined by the differential signaling of prokineticin 2 from the intrinsically photosensitive retinal ganglion cells onto their retinorecipient brain targets.

Indexed as

ArousalCircadian RhythmSignal TransductionAnimalsBiological ClocksGastrointestinal HormonesHaplorhiniLightMelanopsinMiceModels, BiologicalMotor ActivityNeuropeptidesRetinal Ganglion CellsRod OpsinsTime FactorsGastrointestinal HormonesMelanopsinNeuropeptidesProk2 protein, mouseRod OpsinsCircadian clock outputDiurnalIntrinsically photosensitive retinal ganglion cellsNocturnalOscillationProkineticin 2SleepSuperior colliculusSuprachiasmatic nucleusWakefulness

Identifiers

PMID27535380
PMCPMC4989352
OpenAlexW2477228728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.