ArticleJournal of neurophysiology2016
Interactive effect of acute pain and motor learning acquisition on sensorimotor integration and motor learning outcomes.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Motor Learning in Response to Different Experimental Pain Models Among Healthy Individuals: A Systematic Review.Frontiers in human neuroscience · 2022Pooled it
- Sensorimotor Integration and Pain Perception: Mechanisms Integrating Nociceptive Processing. A Systematic Review and ALE-Meta Analysis.Frontiers in integrative neuroscience · 2022Pooled it
- Exploring pain interference with motor skill learning in humans: A systematic review.PloS one · 2022Pooled it
- A Single Session of Slackline Training Induces Rapid, Task-Specific Balance Improvements and Elevated Resting-State Beta Band Power.European journal of sport science · 2026Trial
- Acute pain impairs retention of locomotor learning.Journal of neurophysiology · 2024Trial
- The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.The Journal of the Canadian Chiropractic Association · 2025Article
- Effect of Phasic Experimental Pain Applied during Motor Preparation or Execution on Motor Performance and Adaptation in a Reaching Task: A Randomized Trial.Brain sciences · 2024Article
- Development of the Sensory-Motor Dysfunction Questionnaire and Pilot Reliability Testing.Brain sciences · 2024Article
- Sensorimotor integration and motor learning during a novel force-matching task in young adults with attention-deficit/hyperactivity disorder.Frontiers in human neuroscience · 2022Article
- Effect of Neck Muscle Fatigue on Hand Muscle Motor Performance and Early Somatosensory Evoked Potentials.Brain sciences · 2021Article
- Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans.Scientific reports · 2021Article
- Exploring pain interference with motor skill learning in humans: a protocol for a systematic review.BMJ open · 2021Article
- Differential Changes in Early Somatosensory Evoked Potentials between the Dominant and Non-Dominant Hand, Following a Novel Motor Tracing Task.Brain sciences · 2020Article
- Pain Intensity and Functional Outcomes for Activities of Daily Living, Gait and Balance in Older Adults Accessing Outpatient Rehabilitation Services: A Retrospective Study.Journal of pain research · 2020Article
- The Influence of Subclinical Neck Pain on Neurophysiological and Behavioral Measures of Multisensory Integration.Brain sciences · 2019Article
- The Interactive Effect of Tonic Pain and Motor Learning on Corticospinal Excitability.Brain sciences · 2019Article
- Does Location of Tonic Pain Differentially Impact Motor Learning and Sensorimotor Integration?Brain sciences · 2018Article
- Differential Corticomotor Excitability Responses to Hypertonic Saline-Induced Muscle Pain in Forearm and Hand Muscles.Neural plasticity · 2018Article
- Effect of pain on deafferentation-induced modulation of somatosensory evoked potentials.PloS one · 2018Article
- Effect of Cutaneous Heat Pain on Corticospinal Excitability of the Tibialis Anterior at Rest and during Submaximal Contraction.Neural plasticity · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous work has demonstrated differential changes in early somatosensory evoked potentials (SEPs) when motor learning acquisition occurred in the presence of acute pain; however, the learning task was insufficiently complex to determine how these underlying neurophysiological differences impacted learning acquisition and retention. To address this limitation, we have utilized a complex motor task in conjunction with SEPs. Two groups of 12 participants (n = 24) were randomly assigned to either a capsaicin (capsaicin cream) or a control (inert lotion) group. SEP amplitudes were collected at baseline, after application, and after motor learning acquisition. Participants performed a motor acquisition task followed by a pain-free retention task within 24-48 h. After motor learning acquisition, the amplitude of the N20 SEP peak significantly increased (P < 0.05) and the N24 SEP peak significantly decreased (P < 0.001) for the control group while the N18 SEP peak significantly decreased (P < 0.01) for the capsaicin group. The N30 SEP peak was significantly increased (P < 0.001) after motor learning acquisition for both groups. The P25 SEP peak decreased significantly (P < 0.05) after the application of capsaicin cream. Both groups improved in accuracy after motor learning acquisition (P < 0.001). The capsaicin group outperformed the control group before motor learning acquisition (P < 0.05) and after motor learning acquisition (P < 0.05) and approached significance at retention (P = 0.06). Improved motor learning in the presence of capsaicin provides support for the enhancement of motor learning while in acute pain. In addition, the changes in SEP peak amplitudes suggest that early SEP changes reflect neurophysiological alterations accompanying both motor learning and mild acute pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.