Evidence map›Paper›PMID 27535299›Full record

ArticleScientific reports2016

Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System.

Chen Lin, Yi-Chung Chang, Ya-Chen Cheng, Po-Jung Lai, Chien-Hung Yeh, Wan-Hsin Hsieh, Kun Hu, June-Tai Wu, Hsiu-Hsiang Lee, Men-Tzung Lo and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chen LinDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan city, Taiwan.
Yi-Chung ChangDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan city, Taiwan.
Ya-Chen ChengInstitue of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Po-Jung LaiDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Chien-Hung YehDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan city, Taiwan.
Wan-Hsin HsiehDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan city, Taiwan.
Kun HuMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
June-Tai WuInstitue of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Hsiu-Hsiang LeeInstitue of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Men-Tzung LoDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan city, Taiwan.
Yi-Lwun HoDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
National Central University · TWNational Taiwan University · TWNational Taiwan University Hospital · TWHarvard University · US

Funding

TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI QUAN, STUART F. · 1991 to 2018
$23.1M
Neuropathology for disrupted multiscale activity control in Alzheimer's diseaseR01AG048108 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2015 to 2018
$1.6M
Fractal Regulatory Function of the Circadian SystemR00HL102241 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2012 to 2014
$720k
NHLBI NIH HHS R00 HL102241NIA NIH HHS P01 AG009975NIA NIH HHS R01 AG048108
6 · The paper itself

Abstract

Judiciously tuning heart rates is critical for regular cardiovascular function. The fractal pattern of heartbeats - a multiscale regulation in instantaneous fluctuations - is well known for vertebrates. The most primitive heart system of the Drosophila provides a useful model to understand the evolutional origin of such a fractal pattern as well as the alterations of fractal pattern during diseased statuses. We developed a non-invasive visible optical heart rate recording system especially suitable for long-term recording by using principal component analysis (PCA) instead of fluorescence recording system to avoid the confounding effect from intense light irradiation. To deplete intracellular Ca(2+) levels, the expression of sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) was tissue-specifically knocked down. The SERCA group shows longer heart beat intervals (Mean ± SD: 1009.7 ± 151.6 ms) as compared to the control group (545.5 ± 45.4 ms, p < 0.001). The multiscale correlation of SERCA group (scaling exponent: 0.77 ± 0.07), on the other hand, is weaker than that of the control Drosophila (scaling exponent: 0.85 ± 0.03) (p = 0.016).

Indexed as

FractalsHeart RateAnimalsCalciumDrosophilaEndoplasmic ReticulumLarvaOptical DevicesPrincipal Component AnalysisSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID27535299
PMCPMC4989149
OpenAlexW2513838997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.