Evidence map›Paper›PMID 27535297›Full record

ArticleAIDS care2017

Forget about forgetting: structural barriers and severe non-adherence to antiretroviral therapy.

Seth C Kalichman, Moira O Kalichman, Chauncey Cherry

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Seth C Kalichmana Department of Psychology , University of Connecticut , Storrs , CT , USA.
Moira O Kalichmana Department of Psychology , University of Connecticut , Storrs , CT , USA.
Chauncey Cherrya Department of Psychology , University of Connecticut , Storrs , CT , USA.
University of Connecticut · US

Funding

Behavioral Intervention to Enhance HIV Test/TreatR01DA033067 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2012 to 2016
$3.3M
Influence of Food Insecurity on AdherenceR01AA021471 · NIAAA · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2013 to 2015
$941k
NIAAA NIH HHS R01 AA021471NIDA NIH HHS R01 DA033067
6 · The paper itself

Abstract

HIV infection is now clinically manageable with antiretroviral therapy (ART). However, a significant number of people with HIV do not benefit from ART because of non-adherence. This study examined the use of adherence strategies and barriers to adherence among persons at substantial risk for developing resistant virus (less than 75% adherent). People living with HIV (n = 556) who were less than 95% adherent to ART completed computerized interviews, were screened for active drug use, provided medical records for HIV viral load, and completed unannounced pill counts to monitor ART adherence and an assessment of adherence barriers. Based on pill counts, participants were defined as severely non-adherent (≤75% medications taken) and moderately non-adherent (>75% and <95% adherent). Results showed a broad array of memory devices were used to no avail across non-adherence groups. Individuals who were severely non-adherent were significantly more likely to attribute missing medications due to substance use and structural barriers, including running out of medications, inability to get to pharmacy, and inability to afford medications. Results suggest that interventions focused on memory lapses will be insufficient and should rather concentrate on substance use treatment and providing case management to resolve structural barriers to adherence.

Indexed as

Medication AdherenceAdultAnti-HIV AgentsFemaleHealth Services AccessibilityHIV InfectionsHumansMaleMiddle AgedPharmaciesSubstance-Related DisordersAnti-HIV Agentsadherence barriersHIV treatmentmedication adherence

Identifiers

PMID27535297
PMCPMC5593131
OpenAlexW2508302965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.