ArticleMolecular and cellular biochemistry2016
Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration.
Article in Molecular and cellular biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- The Interplay Between Stiffness and Hyperglycemia on Diabetic Foot Ulcer Wound Closure.Cellular and molecular bioengineering · 2026Article
- Exploring the Effects of Metformin on the Body via the Urine Proteome.Biomolecules · 2025Article
- New insights into the role of cellular senescence and chronic wounds.Frontiers in endocrinology · 2024Review
- Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: A review.International wound journal · 2023Review
- Effects ofFood science & nutrition · 2023Article
- Changes in miroRNA-103 expression in wound margin tissue are related to wound healing of diabetes foot ulcers.International wound journal · 2023Article
- Advanced Glycation End Products Effects on Adipocyte Niche Stiffness and Cell Signaling.International journal of molecular sciences · 2023Article
- Eicosapentaenoic acid-rich oil supplementation activates PPAR-γ and delays skin wound healing in type 1 diabetic mice.Frontiers in immunology · 2023Article
- Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity.Frontiers in endocrinology · 2020Review
- The Impact of Diabetic Conditions and AGE/RAGE Signaling on Cardiac Fibroblast Migration.Frontiers in cell and developmental biology · 2020Article
- Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling.Oncogenesis · 2019Article
- Diabetes mellitus increased integrins gene expression in rat endometrium at the time of embryo implantation.International journal of reproductive biomedicine · 2019Article
- Metallic nanoparticles reduce the migration of human fibroblasts in vitro.Nanoscale research letters · 2017Article
- Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition.Antioxidants & redox signaling · 2017Review
- The impact of quercetin on wound healing relates to changes in αV and β1 integrin expression.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Fibroblast paracrine TNF-α signaling elevates integrin A5 expression in idiopathic pulmonary fibrosis (IPF).Respiratory research · 2017Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deficient wound healing is a common multifactorial complication in diabetic patients, but the cellular and molecular mechanisms involved are poorly defined. In the present study, we analyzed the effects of hyperglycemia on integrins expression in rat dermal fibroblasts and addressed its role in cell adhesion and migration. Diabetes Mellitus was induced in rats by streptozotocin injection and maintained for 30 days. Primary cultures of dermal fibroblasts from control and diabetic rats were maintained under low glucose (5 mM D-glucose) or high glucose (30 mM D-glucose) for 7 days. Cell adhesion and migration were studied by kymography, transwell, and time-lapse assays, and the expressions of integrin subunits αv and α5 were studied by immunocytochemistry and western blotting. Fibroblasts derived from diabetic rats confirmed a reduced migration speed and delayed spreading compared to fibroblasts derived from control rats. The membrane fraction of diabetic-derived fibroblasts showed a decrease of integrin subunits α5 and αv, which was confirmed by immunocytochemistry assays. A reduction in the pericellular fibronectin matrix was also observed. The exposure of diabetic-derived cells to a higher concentration of exogenous fibronectin improved migration velocity and the expression of αv but did not completely restore their migration capacity. In conclusion, the mechanisms involved in the deleterious effects of Diabetes Mellitus on wound healing include the ability of fibroblasts to secrete and to adhere to fibronectin.
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