Evidence map›Paper›PMID 27535221›Full record

ArticleThe Journal of biological chemistry2016

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.

Urška Slapšak, Giulia Salzano, Ladan Amin, Romany N N Abskharon, Gregor Ilc, Blaž Zupančič, Ivana Biljan, Janez Plavec, Gabriele Giachin, Giuseppe Legname

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Prion Protein: The Molecule of Many Forms and Faces.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. A soluble derivative of PrPThe Journal of biological chemistry · 2020
    Article
  13. Prion Protein at the Leading Edge: Its Role in Cell Motility.International journal of molecular sciences · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Prion disease.Handbook of clinical neurology · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 7 countries.

Urška SlapšakFrom the Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
Giulia Salzanothe Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, Trieste I-34136, Italy.
Ladan Aminthe Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, Trieste I-34136, Italy.
Romany N N Abskharonthe Structural Biology Research Center, Vrije Universiteit Brussel, VIB, Pleinlaan 2, 1050, Brussels, Belgium, the National Institute of Oceanography and Fisheries (NIOF), 11516 Cairo, Egypt, and the Van Andel Research Institute, Grand Rapids, Michigan 49503.
Gregor IlcFrom the Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia, the EN-FIST Centre of Excellence, Dunajska 156, SI-1000 Ljubljana, Slovenia.
Blaž ZupančičFrom the Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
Ivana Biljanthe Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A, Zagreb HR-10000, Croatia.
Janez PlavecFrom the Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia, the EN-FIST Centre of Excellence, Dunajska 156, SI-1000 Ljubljana, Slovenia, the Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia, janez.plavec@ki.si.
Gabriele Giachinthe Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, Trieste I-34136, Italy, the Structural Biology Group, European Synchrotron Radiation Facility (ESRF), 71 Avenue des Martyrs, 38000-Grenoble, France.
Giuseppe Legnamethe Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, Trieste I-34136, Italy, legname@sissa.it.
National Institute of Chemistry · SIScuola Internazionale Superiore di Studi Avanzati · ITEuropean Synchrotron Radiation Facility · FRUniversity of Zagreb · HRVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cellular form of the prion protein (PrP

Indexed as

AnimalsHippocampusHumansMiceNeural Cell Adhesion MoleculesNeuronsNuclear Magnetic Resonance, BiomolecularProtein DomainsPrPC ProteinsNeural Cell Adhesion MoleculesPrPC Proteinscell adhesionfibronectinfibronectin type-3 domainNCAMNMR spectroscopynuclear magnetic resonance (NMR)prionprion proteinprotein-protein interactionSTEDstimulated emission depletion microscopy

Identifiers

PMID27535221
PMCPMC5063971
OpenAlexW2508054732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.