Evidence map›Paper›PMID 27535140›Full record

ArticleMolecular & cellular proteomics : MCP2016

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome.

Fiorella A Solari, Nadine J A Mattheij, Julia M Burkhart, Frauke Swieringa, Peter W Collins, Judith M E M Cosemans, Albert Sickmann, Johan W M Heemskerk, René P Zahedi

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Guideline
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  9. Review
  10. Suppressed ORAI1-STIM1-dependent CaThe Journal of biological chemistry · 2024
    Article
  11. Article
  12. Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Proteomics: A Tool to Study Platelet Function.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Fiorella A SolariFrom the ‡Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Nadine J A Mattheij§Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Julia M BurkhartFrom the ‡Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Frauke Swieringa§Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Peter W Collins¶Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Judith M E M Cosemans§Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Albert SickmannFrom the ‡Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany; ‖Medizinisches Proteom-Center, Ruhr-University Bochum, Bochum, Germany; **Department of Chemistry, College of Physical Sciences, University of Aberdeen, Aberdeen, UK.
Johan W M Heemskerk§Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; rene.zahedi@isas.de jwm.heemskerk@maastrichtuniversity.nl.
René P ZahediFrom the ‡Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany; rene.zahedi@isas.de jwm.heemskerk@maastrichtuniversity.nl.
Maastricht University · NLLeibniz Institute for Analytical Sciences - ISAS · DECardiff University · GBUniversity of Aberdeen · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Scott syndrome is a very rare and likely underdiagnosed bleeding disorder associated with mutations in the gene encoding anoctamin-6. Platelets from Scott patients are impaired in various Ca

Indexed as

Blood Coagulation DisordersBlood PlateletsCalciumCrotalid VenomsGene Expression RegulationHumansIonomycinLectins, C-TypePhosphoproteinsProteolysisProteomicsSignal TransductionThrombinCalciumconvulxinCrotalid VenomsIonomycinLectins, C-TypePhosphoproteinsThrombin

Identifiers

PMID27535140
PMCPMC5054341
OpenAlexW2514962374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.