Evidence map›Paper›PMID 27535137›Full record

ArticleProtein & cell2016

Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells.

Jiaming Su, Yi Sui, Jian Ding, Fuqiang Li, Shuang Shen, Yang Yang, Zeming Lu, Fei Wang, Lingling Cao, Xiaoxia Liu and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Yin Yang 1: Function, Mechanisms, and Glia.Neurochemical research · 2025
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  9. YY1 Silencing Induces 5-Fluorouracil-Resistance andInternational journal of molecular sciences · 2021
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Jiaming SuSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Yi SuiSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Jian DingSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Fuqiang LiSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Shuang ShenSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Yang YangSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Zeming LuSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Fei WangSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Lingling CaoSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Xiaoxia LiuDepartment of Gynecologic Oncology, The First Clinical Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
Jingji JinSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China. jjjin@jlu.edu.cn.ORCID http://orcid.org/0000-0001-9432-5954
Yong CaiSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China. caiyong62@jlu.edu.cn.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The BCCIP (BRCA2- and CDKN1A-interacting protein) is an important cofactor for BRCA2 in tumor suppression. Although the low expression of BCCIP is observed in multiple clinically diagnosed primary tumor tissues such as ovarian cancer, renal cell carcinoma and colorectal carcinoma, the mechanism of how BCCIP is regulated in cells is still unclear. The human INO80/YY1 chromatin remodeling complex composed of 15 subunits catalyzes ATP-dependent sliding of nucleosomes along DNA. Here, we first report that BCCIP is a novel target gene of the INO80/YY1 complex by presenting a series of experimental evidence. Gene expression studies combined with siRNA knockdown data locked candidate genes including BCCIP of the INO80/YY1 complex. Silencing or over-expressing the subunits of the INO80/YY1 complex regulates the expression level of BCCIP both in mRNA and proteins in cells. Also, the functions of INO80/YY1 complex in regulating the transactivation of BCCIP were confirmed by luciferase reporter assays. Chromatin immunoprecipitation (ChIP) experiments clarify the enrichment of INO80 and YY1 at +0.17 kb downstream of the BCCIP transcriptional start site. However, this enrichment is significantly inhibited by either knocking down INO80 or YY1, suggesting the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex.

Indexed as

ATPases Associated with Diverse Cellular ActivitiesCalcium-Binding ProteinsCell Cycle ProteinsChromatin Assembly and DisassemblyDNA-Binding ProteinsDNA HelicasesHeLa CellsHumansMultiprotein ComplexesNuclear ProteinsPromoter Regions, GeneticTranscription, GeneticYY1 Transcription FactorATPases Associated with Diverse Cellular ActivitiesBCCIP protein, humanCalcium-Binding ProteinsCell Cycle ProteinsDNA-Binding ProteinsDNA HelicasesINO80 protein, humanMultiprotein ComplexesNuclear ProteinsYY1 protein, humanYY1 Transcription FactorBCCIPchromatin remodeling complexhuman INO80

Identifiers

PMID27535137
PMCPMC5055488
OpenAlexW2512025345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.