Evidence map›Paper›PMID 27535007›Full record

ArticleBritish journal of pharmacology2016

Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2.

Elvira Santiago, Maria Pilar Martínez, Belén Climent, Mercedes Muñoz, Ana María Briones, Mercedes Salaices, Albino García-Sacristán, Luis Rivera, Dolores Prieto

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Assessment of the correlation between oxidative stress and expression ofArchives of medical sciences. Atherosclerotic diseases · 2021
    Article
  6. Article
  7. The deleterious role of the prostaglandin EAmerican journal of physiology. Heart and circulatory physiology · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elvira SantiagoDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Maria Pilar MartínezDepartamento de Anatomía and Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
Belén ClimentDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Mercedes MuñozDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Ana María BrionesDepartamento de Farmacología, Facultad de Medicina, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Universidad Autónoma de Madrid, Madrid, Spain.
Mercedes SalaicesDepartamento de Farmacología, Facultad de Medicina, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Universidad Autónoma de Madrid, Madrid, Spain.
Albino García-SacristánDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Luis RiveraDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Dolores PrietoDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain. dprieto@ucm.es.
Universidad Complutense de Madrid · ESHospital Universitario La Paz · ESUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeOxidative stress plays a key role in the vascular and metabolic abnormalities associated with obesity. Herein, we assessed whether obesity can increase coronary vasoconstriction induced by hydrogen peroxide (H EXPERIMENTAL APPROACH: Contractile responses to H KEY

resultsBoth basal and H CONCLUSION AND IMPLICATIONS: COX-2 contributes to cardiac oxidative stress and to the endothelium-independent O

Indexed as

AnimalsCoronary VesselsCyclooxygenase 2Hydrogen PeroxideMaleObesityOxidative StressRatsRats, ZuckerVasoconstrictionCyclooxygenase 2Hydrogen Peroxide

Identifiers

PMID27535007
PMCPMC5071563
OpenAlexW2514228319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.