Evidence map›Paper›PMID 27534879›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016

Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats.

Frank T Spradley, Jennifer M Sasser, Jacqueline B Musall, Jennifer C Sullivan, Joey P Granger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Frank T SpradleyDepartment of Surgery, The University of Mississippi Medical Center, Jackson, Mississippi; fspradley@umc.edu.
Jennifer M SasserDepartment of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, Mississippi.
Jacqueline B MusallDepartment of Physiology, Augusta University, Augusta, Georgia.
Jennifer C SullivanDepartment of Physiology, Augusta University, Augusta, Georgia.
Joey P GrangerDepartment of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, Mississippi.
Augusta University · USUniversity of Mississippi Medical Center · USJackson Memorial Hospital · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Hypertension, Kidney and PregnancyR01HL108618 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2011 to 2015
$1.8M
Mechanisms of Renoprotection by Relaxin in HypertensionK01DK095018 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI SASSER, JENNIFER M · 2012 to 2016
$634k
NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL108618NHLBI NIH HHS T32 HL105324NIDDK NIH HHS K01 DK095018NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

Although obesity increases the risk for hypertension in pregnancy, the mechanisms responsible are unknown. Increased nitric oxide (NO) production results in vasodilation and reduced blood pressure during normal pregnancy in lean rats; however, the role of NO is less clear during obese pregnancies. We examined the impact of obesity on NO synthase (NOS)-mediated regulation of blood pressure during pregnancy by testing the hypothesis that NOS activity, expression, and regulation of vascular tone and blood pressure are reduced in obese pregnant rats. At gestational day 19, melanocortin-4 receptor (MC4R)-deficient obese rats (MC4R) had greater body weight and fat mass with elevated blood pressure and circulating sFlt-1 levels compared with MC4R pregnant rats. MC4R pregnant rats also had less circulating cGMP levels and reduced total NOS enzymatic activity and expression in mesenteric arteries. Despite decreased biochemical measures of NO/NOS in MC4R rats, NOS inhibition enhanced vasoconstriction only in mesenteric arteries from MC4R rats, suggesting greater NOS-mediated tone. To examine the role of NOS on blood pressure regulation in obese pregnant rats, MC4R and MC4R pregnant rats were administered the nonselective NOS inhibitor N

Indexed as

Blood PressureAnimalsFemaleHypertensionNitric OxideNitric Oxide SynthaseObesityPregnancyPregnancy ComplicationsRatsReceptor, Melanocortin, Type 4Vasodilationmelanocortin receptor type 4, ratNitric OxideNitric Oxide SynthaseReceptor, Melanocortin, Type 4hypertensionl-NAMEMC4Rpreeclampsiawomen’s health

Identifiers

PMID27534879
PMCPMC5130576
OpenAlexW2518185002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.