ArticleScientific reports2016
Post-Testicular Sperm Maturation: Centriole Pairs, Found in Upper Epididymis, are Destroyed Prior to Sperm's Release at Ejaculation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The spermatozoon neck role in infertility and intracytoplasmic sperm injection outcomes.Journal of assisted reproduction and genetics · 2026Review
- Meiotic progression in multinuclear mouse spermatocytes without the spindle pole clustering motor protein KIFC1 or cytokinesis forms single-cell late-stage spermatids.Scientific reports · 2025Article
- Article
- Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.Scientific reports · 2024Article
- Reduction, proliferation, and differentiation defects of stem cells over time: a consequence of selective accumulation of old centrioles in the stem cells?Molecular biology reports · 2023Review
- The Centriole's Role in Miscarriages.Frontiers in cell and developmental biology · 2022Article
- Time-lapse imaging of human embryos fertilized with testicular sperm reveals an impact on the first embryonic cell cycle.Biology of reproduction · 2021Article
- Semen quality and windows of susceptibility: A case study during COVID-19 outbreak in China.Environmental research · 2021Observational
- Early production of offspring by in vitro fertilization using first-wave spermatozoa from prepubertal male mice.The Journal of reproduction and development · 2019Article
- It takes two (centrioles) to tango.Reproduction (Cambridge, England) · 2019Review
- The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis.Results and problems in cell differentiation · 2019Review
- Separation and Loss of Centrioles From Primordidal Germ Cells To Mature Oocytes In The Mouse.Scientific reports · 2018Article
- Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility.The FEBS journal · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fertilizing sperm's lengthiest unchartered voyage is through the longest, least-investigated organ in a man's body - the Epididymis. Over six meters long in men, ~80 meters in stallions and over one-hundred times a mouse's body length, there are few functions known aside from sperm storage and nutrition. While spermatogenesis is completed in the testes, here we demonstrate sperm centriole reduction occurs within the epididymis. Investigations of GFP-CENTR mice and controls demonstrate both the presence of centriole pairs in the upper caput region of the epididymis and, the destruction, first, of the distal and, then, of the proximal centriole as the sperm transits to the cauda and vas deferens in preparation for its climactic release. These centrioles can neither recruit γ-tubulin nor nucleate microtubules when eggs are inseminated or microinjected, yet numerous maternally-nucleated cytasters are found. These sperm centrioles appear as vestigial basal bodies, destroyed in the mid-to-lower corpus. Post-testicular sperm maturation, in which sperm centrioles found in the caput are destroyed prior to ejaculation, is a newly discovered function for the epididymis.
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