ArticleThe Journal of infectious diseases2016
Severe Flooding and Malaria Transmission in the Western Ugandan Highlands: Implications for Disease Control in an Era of Global Climate Change.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Impact of flooding events on waterborne and vector-borne infections: a systematic review.BMC infectious diseases · 2026Pooled it
- Performance of rapid diagnostic tests for malaria diagnosis in Nigeria: a systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Epidemiology of floods in sub-Saharan Africa: a systematic review of health outcomes.BMC public health · 2022Pooled it
- Permethrin-Treated Baby Wraps for the Prevention of Malaria.The New England journal of medicine · 2025Trial
- Dihydroartemisinin-Piperaquine Chemoprevention and Malaria Incidence After Severe Flooding: Evaluation of a Pragmatic Intervention in Rural Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Malaria among children living in flood-prone villages in the Kasese District of Western Uganda: prevalence and risk factors from a cross-sectional study.Research square · 2026Article
- Explainable Machine Learning for Predicting Global Malaria Incidence From 2000 to 2022 With Climatic and Extreme Weather Conditions Across 78 Endemic Countries: A Retrospective Ecological Study.Health science reports · 2026Article
- Article
- Contemporary Anopheles vector species distribution in Scotland and its association with historical hotspots of malaria transmission.Malaria journal · 2026Article
- Climate change policies and health in Uganda: where are we headed?International health · 2026Article
- Geospatial mapping of malaria risk in flood-prone zones of Sub-Saharan Africa.Scientific reports · 2026Article
- Warming temperatures reduce lifespan and vectorial capacity of Anopheles mosquitoes in Ghana.Infectious Disease Modelling · 2026Article
- Climate change and infectious diseases.Nature medicine · 2026Review
- Malaria at the margins: climatic extremes, migration, and urban informal settlement risk in South Africa.Malaria journal · 2026Article
- Community perceptions on climate change and its impacts on malaria transmission in South-eastern Tanzania.Malaria journal · 2026Article
- Effects of hydro-meteorological and geological disasters on vaccine-preventable disease outbreaks and routine immunisation amongst children: A scoping review.PLOS global public health · 2026Article
- Examining the effects of climate and environmental hazards on vector and water-borne diseases in Eastern Uganda.Discover Environment · 2026Article
- Community experiences of the impacts of climate-induced extreme weather events in Uganda: A qualitative study.PLOS global public health · 2026Article
- Extreme weather and climate-related adverse childhood experiences are a humanitarian crisis during the 21st century.Communications medicine · 2025Review
- Malaria: past, present, and future.Signal transduction and targeted therapy · 2025Review
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThere are several mechanisms by which global climate change may impact malaria transmission. We sought to assess how the increased frequency of extreme precipitation events associated with global climate change will influence malaria transmission in highland areas of East Africa.
methodsWe used a differences-in-differences, quasi-experimental design to examine spatial variability in the incidence rate of laboratory-confirmed malaria cases and malaria-related hospitalizations between villages (1) at high versus low elevations, (2) with versus without rivers, and (3) upstream versus downstream before and after severe flooding that occurred in Kasese District, Western Region, Uganda, in May 2013.
resultsDuring the study period, 7596 diagnostic tests were performed, and 1285 patients were admitted with a diagnosis of malaria. We observed that extreme flooding resulted in an increase of approximately 30% in the risk of an individual having a positive result of a malaria diagnostic test in the postflood period in villages bordering a flood-affected river, compared with villages farther from a river, with a larger relative impact on upstream versus downstream villages (adjusted rate ratio, 1.91 vs 1.33).
conclusionsExtreme precipitation such as the flooding described here may pose significant challenges to malaria control programs and will demand timely responses to mitigate deleterious impacts on human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.