Evidence map›Paper›PMID 27534643›Full record

ArticleThe American journal of clinical nutrition2016

Prospective study of serum cysteine and cysteinylglycine and cancer of the head and neck, esophagus, and stomach in a cohort of male smokers.

Eugenia H Miranti, Neal D Freedman, Stephanie J Weinstein, Christian C Abnet, Jacob Selhub, Gwen Murphy, Lena Diaw, Satu Männistö, Philip R Taylor, Demetrius Albanes and 1 more

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00342992 (Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00342992 completednot on this map

Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) Population

TypeobservationalSponsorNational Cancer Institute (NCI)Ran1995 to 2020Enrolled29,133ConditionsStroke, Diabetes Mellitus, Heart Disease, Cancer
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Eugenia H MirantiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD; freedmanne@mail.nih.gov.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
Jacob SelhubJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;
Gwen MurphyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
Lena DiawPulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, NIH, Department of Health and Human Services, Bethesda, MD; and.
Satu MännistöDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD;
National Cancer Institute · USFinnish Institute for Health and Welfare · FINational Heart Lung and Blood Institute · USTufts University · US

Funding

Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5M
6 · The paper itself

Abstract

backgroundThe nonessential amino acid cysteine is known to be involved in many antioxidant and anticarcinogenic pathways. Cysteinylglycine is a pro-oxidant metabolite of glutathione and a precursor of cysteine.

objectiveTo examine the relation between serum cysteine and cysteinylglycine and risk of gastric adenocarcinomas, esophageal squamous cell carcinomas, and head and neck squamous cell carcinomas, we conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study of male Finnish smokers aged 50-69 y at baseline.

designIn total, 170 gastric adenocarcinomas, 68 esophageal squamous cell carcinomas, and 270 head and neck squamous cell carcinomas (identified from the Finnish Cancer Registry) were matched one-to-one with cancer-free control subjects on age and the date of serum collection. We calculated ORs and 95% CIs with the use of a multivariate-adjusted conditional logistic regression.

resultsCysteine had a U-shaped association with gastric adenocarcinomas; a model that included a linear and a squared term had a significant global P-test (P = 0.036). Serum cysteinylglycine was inversely associated with adenocarcinomas of the gastric cardia (OR for above the median compared with below the median: 0.07; 95% CI: 0.01, 0.70; n = 38 cases) but not for other sites. Both cysteine and cysteinylglycine were not associated with esophageal squamous cell carcinoma or head and neck squamous cell carcinoma.

conclusionsWe observed associations between serum cysteine and cysteinylglycine with upper gastrointestinal cancer risk. Future studies are needed to replicate these findings. This trial was registered at clininicaltrials.gov as NCT00342992.

Indexed as

AdenocarcinomaAntioxidantsBiomarkersCarcinoma, Squamous CellCase-Control StudiesCohort StudiesCysteineDeficiency DiseasesDietary SupplementsDipeptidesFinlandHead and Neck NeoplasmsHumansHyperhomocysteinemiaIncidenceMaleAntioxidantsBiomarkersCysteinecysteinylglycineDipeptidescysteineesophageal neoplasmshead and neck neoplasmsstomach neoplasmsupper gastrointestinal tract cancers

Identifiers

PMID27534643
PMCPMC4997291
OpenAlexW2507530786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.