Evidence map›Paper›PMID 27534634›Full record

Trial reportThe American journal of clinical nutrition2016

Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial.

Seth Adu-Afarwuah, Anna Lartey, Harriet Okronipa, Per Ashorn, Janet M Peerson, Mary Arimond, Ulla Ashorn, Mamane Zeilani, Stephen Vosti, Kathryn G Dewey

2 registry-linked trialsOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 91 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 14 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00970866 nacompletednot on this map

Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants

TypeinterventionalSponsorUniversity of California, DavisRan2009 to 2017Enrolled3,499ConditionsAnemia, Malnutrition, StuntingArmsIron and Folic Acid (IFA), Multiple Micronutrient (MMN) group, Lipid-based Nutrient Supplements (LNS) group
NCT03448484 nacompletednot on this mapstarted 2018, after this paper: background citation

Programme Effectiveness of an Integrated Programme to Reduce Maternal and Child Malnutrition in Kenya: Cluster Randomized, Parallel-group, Prospective, Follow-up Effectiveness Study in Children 6-35 Months of Age at Recruitment

TypeinterventionalSponsorFabian RohnerRan2018 to 2020Enrolled1,927ConditionsStuntingArmsIntervention (integrated package), Control
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 14 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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  12. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana; ct3665@gmail.com.ORCID http://orcid.org/0000-0002-2720-5474
Anna LarteyDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana;ORCID http://orcid.org/0000-0002-7870-2606
Harriet OkronipaDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana;ORCID http://orcid.org/0000-0002-5373-6754
Per AshornCenter for Child Health Research, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland;ORCID http://orcid.org/0000-0003-2311-2593
Janet M PeersonProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA; and.ORCID http://orcid.org/0000-0001-6816-1909
Mary ArimondProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA; and.
Ulla AshornCenter for Child Health Research, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland;ORCID http://orcid.org/0000-0002-1720-868X
Mamane ZeilaniNutriset S.A.S., Malaunay, France.ORCID http://orcid.org/0000-0003-4566-6394
Stephen VostiProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA; and.
Kathryn G DeweyProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA; and.
University of California, Davis · USUniversity of Ghana · GHTampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildhood stunting usually begins in utero and continues after birth; therefore, its reduction must involve actions across different stages of early life.

objectiveWe evaluated the efficacy of small-quantity, lipid-based nutrient supplements (SQ-LNSs) provided during pregnancy, lactation, and infancy on attained size by 18 mo of age.

designIn this partially double-blind, individually randomized trial, 1320 women at ≤20 wk of gestation received standard iron and folic acid (IFA group), multiple micronutrients (MMN group), or SQ-LNS (LNS group) daily until delivery, and then placebo, MMNs, or SQ-LNS, respectively, for 6 mo postpartum; infants in the LNS group received SQ-LNS formulated for infants from 6 to 18 mo of age (endline). The primary outcome was child length by 18 mo of age.

resultsAt endline, data were available for 85% of 1228 infants enrolled; overall mean length and length-for-age z score (LAZ) were 79.3 cm and -0.83, respectively, and 12% of the children were stunted (LAZ <-2). In analysis based on the intended treatment, mean ± SD length and LAZ for the LNS group (79.7 ± 2.9 cm and -0.69 ± 1.01, respectively) were significantly greater than for the IFA (79.1 ± 2.9 cm and -0.87 ± 0.99) and MMN (79.1 ± 2.9 cm and -0.91 ± 1.01) groups (P = 0.006 and P = 0.009, respectively). Differences were also significant for weight and weight-for-age z score but not head or midupper arm circumference, and the prevalence of stunting in the LNS group was 8.9%, compared with 13.7% in the IFA group and 12.9% in the MMN group (P = 0.12). In analysis based on actual supplement provided at enrollment, stunting prevalences were 8.9% compared with 15.1% and 11.5%, respectively (P = 0.045).

conclusionProvision of SQ-LNSs to women from pregnancy to 6 mo postpartum and to their infants from 6 to 18 mo of age may increase the child's attained length by age 18 mo in similar settings. This trial was registered at clinicaltrials.gov as NCT00970866.

Indexed as

Dietary SupplementsInfant Nutritional Physiological PhenomenaLactationMaternal Nutritional Physiological PhenomenaAdultBody HeightChild DevelopmentDietary FatsDouble-Blind MethodFemaleFetal DevelopmentFetal Growth RetardationGhanaGrowth DisordersHumansInfant, NewbornDietary FatsMicronutrientschild growthhome fortificationlipid-based nutrient supplementsmultiple micronutrientssupplementation

Identifiers

PMID27534634
PMCPMC4997301
OpenAlexW2509558073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.