ArticleThe American journal of clinical nutrition2016
Suggested use of sensitive measures of memory to detect functional effects of maternal iodine supplementation on hippocampal development.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Statistical design considerations applicable to clinical trials of iodine supplementation in pregnant women who may be mildly iodine deficient.The American journal of clinical nutrition · 2016Trial
- Iodine Supplementation Before, During and After Pregnancy.Geburtshilfe und Frauenheilkunde · 2026Article
- A Path Analysis of Nutrition, Stimulation, and Child Development Among Young Children in Bihar, India.Child development · 2018Article
- Assessing infant cognitive development after prenatal iodine supplementation.The American journal of clinical nutrition · 2016Review
- Assessing iodine intake, iodine status, and the effects of maternal iodine supplementation: introduction to articles arising from 3 workshops held by the NIH Office of Dietary Supplements.The American journal of clinical nutrition · 2016Article
- Research needs for assessing iodine intake, iodine status, and the effects of maternal iodine supplementation.The American journal of clinical nutrition · 2016Review
- Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns.The American journal of clinical nutrition · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal hypothyroxinemia secondary to iodine deficiency may have neurodevelopmental effects on the specific neurocognitive domain of memory. Associated disruption of thyroid hormone-dependent protein synthesis in the hippocampus has the potential to result in compromised development of the structure with consequential impairments in memory function. Despite links between maternal iodine deficiency during gestation and lactation and abnormal hippocampal development in rat fetuses and pups, there has been little research on the specific function of memory in human infants and young children born to iodine-deficient mothers. Several candidate measures have proven to be sensitive to the effects of gestational iron deficiency on memory function in infants and young children, including habituation and dishabituation, imitation-based tasks, and event-related potentials. Such measures could be used to test the effects of maternal iodine supplementation on the specific neurocognitive domain of memory in infants and young children. Furthermore, progress in understanding the effects of maternal iodine supplementation on neurocognitive development could be accelerated by the development of a nonhuman primate model to complement the rodent model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.