ArticleDysphagia2017
Modulation of Upper Esophageal Sphincter (UES) Relaxation and Opening During Volume Swallowing.
Article in Dysphagia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial.Journal of oral rehabilitation · 2026Trial
- Pharyngo-Esophageal Modulatory Swallow Responses to Bolus Volume and Viscosity Across Time.The Laryngoscope · 2022Trial
- Effect of Bolus Volume on Upper Esophageal Sphincter Opening: Kinematic Analysis Using 320-Area Detector Computed Tomography.Dysphagia · 2026Article
- Acoustic Features of Airway Protective Maneuvers as Biomarkers of Radiation-Associated Dysphagia and Penetration/Aspiration in Head and Neck Cancer Patients.Head & neck · 2025Article
- Cranial Nerve Deficits Predict Pharyngeal Phase Swallowing Impairment in Patients with Neurogenic Dysphagia: A Cross-Sectional Study.Dysphagia · 2025Article
- Effect of Thickened Fluids on Swallowing Function in Oropharyngeal Dysphagia: Impact of Shear Rheology and Disorder Subtype.Neurogastroenterology and motility · 2025Article
- Chewing Well Modulates Pharyngeal Bolus Transit During Swallowing in Healthy Participants.Dysphagia · 2024Article
- Computed tomography in measuring electrode insertion angle and depth for cricopharyngeal muscle electromyography.Quantitative imaging in medicine and surgery · 2023Article
- The Upper Esophageal Sphincter Distensibility Index Measured Using Functional Lumen Imaging Probe Identifies Defective Barrier Function of the Upper Esophageal Sphincter.Journal of neurogastroenterology and motility · 2022Article
- Changes in tongue pressure and dysphagia at oral cancer patients by palatal augmentation prosthesis.Cancer reports (Hoboken, N.J.) · 2022Article
- Review
- Effects of Varying Transcutaneous Electrical Stimulation Pulse Duration on Swallowing Kinematics in Healthy Adults.Dysphagia · 2022Article
- Variables influencing manometric parameters of deglutitive and non-deglutitive upper esophageal sphincter: A study of 89 asymptomatic participants.Neurogastroenterology and motility · 2022Article
- Biomechanical mechanism of reduced aspiration by the Passy-Muir valve in tracheostomized patients following acquired brain injury: Evidences from subglottic pressure.Frontiers in neuroscience · 2022Article
- Noninvasive Evaluation of the Biomechanical Accommodations to Bolus Volume during Human Swallowing.Applied bionics and biomechanics · 2022Article
- Applying High-Resolution Impedance Manometry for Detecting Swallowing Change in Anterior Cervical Spine Surgery Patients.Frontiers in surgery · 2022Article
- Age-Related Functional Reserve Decline Is Not Seen in Pharyngeal Swallowing Pressures.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Anatomy of inferior end of palatopharyngeus: its contribution to upper esophageal sphincter opening.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Swallowing Pressure Variability as a Function of Pharyngeal Region, Bolus Volume, Age, and Sex.The Laryngoscope · 2021Article
- Impact of Sensory Stimulation on Pharyngo-esophageal Swallowing Biomechanics in Adults with Dysphagia: A High-Resolution Manometry Study.Dysphagia · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
UES opening occurs following cricopharyngeus deactivation and submental muscle contraction causing hyolaryngeal elevation and UES distraction. During impedance manometry, the inverse of impedance (admittance) can be used to measure bolus presence and infer UES opening. We hypothesized that the temporal relationship between UES relaxation, opening and hyolaryngeal elevation would change with increasing bolus volume. Simultaneous intramuscular cricopharyngeal (CP) electromyography (EMG), surface submental EMG (SM-EMG), and high-resolution impedance manometry were recorded in eight (aged 27 ± 7 years, 5 M) healthy volunteers, while swallowing 0.9 % saline boluses of 2, 5, 10, and 20 ml. Data were exported and analyzed via Matlab. Statistical analysis comprised repeated measures one-way ANOVA and Pearson correlation. A P value of <0.05 was considered significant. Duration of CP deactivation increased at 20 ml volume (P < 0.001). UES relaxation and opening increased with increasing bolus volume (P < 0.001); however, overall duration of SM activation did not change. As UES opening occurs progressively earlier with increasing volumes, peak SM-EMG activity occurs relatively later (P < 0.001) and shifts from occurring before to following peak UES distention. During healthy swallowing, there is sensory modulation of cricopharyngeal and submental muscle activity. Intrabolus pressures, transmitted from the tongue base and pharynx, play a progressively more important role in sphincter opening with increasing volume. The findings may explain why some healthy elderly and patients with oropharyngeal dysphagia have difficulty swallowing larger while tolerating smaller bolus volumes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.