Evidence map›Paper›PMID 27534375›Full record

ArticleBrain research2016

Hyperbaric oxygen treatment suppresses withdrawal signs in morphine-dependent mice.

Daniel Nicoara, Yangmiao Zhang, Jordan T Nelson, Abigail L Brewer, Prianka Maharaj, Shea N DeWald, Donald Y Shirachi, Raymond M Quock

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel NicoaraDepartment of Psychology, Washington State University, Pullman, WA, USA.
Yangmiao ZhangDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Jordan T NelsonDepartment of Psychology, Washington State University, Pullman, WA, USA.
Abigail L BrewerDepartment of Psychology, Washington State University, Pullman, WA, USA.
Prianka MaharajDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Shea N DeWaldDepartment of Psychology, Washington State University, Pullman, WA, USA.
Donald Y ShirachiDepartment of Physiology and Pharmacology, University of the Pacific Thomas J. Long School of Pharmacy and Health Sciences, Stockton, CA, USA.
Raymond M QuockDepartment of Psychology, Washington State University, Pullman, WA, USA; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA; Translational Addiction Research Center, Washington State University, Pullman, WA, USA. Electronic address: quockr@wsu.edu.

Funding

Hyperbaric Oxygen: A Novel Approach to Treatment of Chronic PainR21AT007222 · NCCIH · WASHINGTON STATE UNIVERSITY · PI QUOCK, RAYMOND MARK · 2012 to 2013
$401k
NCCIH NIH HHS R21 AT007222
6 · The paper itself

Abstract

Hyperbaric oxygen (HBO2) therapy reportedly reduces opiate withdrawal in human subjects. The purpose of this research was to determine whether HBO2 treatment could suppress physical signs of withdrawal in opiate-dependent mice. Male NIH Swiss mice were injected s.c. with morphine sulfate twice a day for 4 days, the daily dose gradually increasing from 50mg/kg on day 1 to 125mg/kg on day 4. On day 5, withdrawal was precipitated by i.p. injection of 5.0mg/kg naloxone. Mice were observed for physical withdrawal signs, including jumping, forepaw tremor, wet-dog shakes, rearing and defecation for 30min. Sixty min prior to the naloxone injection, different groups of mice received either a 30-min or 60-min HBO2 treatment at 3.5atm absolute. HBO2 treatment significantly reduced naloxone-precipitated jumping, forepaw tremor, wet-dog shakes, rearing and defecation. Based on these experimental findings, we concluded that treatment with HBO2 can suppress physical signs of withdrawal syndrome in morphine-dependent mice.

Indexed as

Hyperbaric OxygenationAnimalsBehavior, AnimalMaleMiceMorphineNaloxoneNarcoticsSubstance Withdrawal SyndromeMorphineNaloxoneNarcoticsHyperbaric oxygenMorphineMouseOpiate withdrawalPhysical dependence

Identifiers

PMID27534375
PMCPMC5018463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.