Evidence map›Paper›PMID 27533942›Full record

ReviewNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2016

Intravenous Fat Emulsion Formulations for the Adult and Pediatric Patient: Understanding the Differences.

Lorenzo Anez-Bustillos, Duy T Dao, Meredith A Baker, Gillian L Fell, Mark Puder, Kathleen M Gura

Abstract readReview
In one paragraph

Review in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Heterogeneity of Biofilm Formation AmongAntibiotics (Basel, Switzerland) · 2025
    Article
  7. Essential fatty acid deficiency in parenteral nutrition: Historical perspective and modern solutions, a narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. SO,MCT,OO,FO-ILE Is Associated With Better Side Effect Profile Than SO-ILE in Critically Ill Children Receiving Parenteral Nutrition.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023
    Article
  17. Article
  18. Article
  19. Optimization, andDrug delivery · 2021
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lorenzo Anez-BustillosVascular Biology Program and the Department of Surgery. Boston Children's Hospital, Boston, Massachusetts, USA.
Duy T DaoVascular Biology Program and the Department of Surgery. Boston Children's Hospital, Boston, Massachusetts, USA.
Meredith A BakerVascular Biology Program and the Department of Surgery. Boston Children's Hospital, Boston, Massachusetts, USA.
Gillian L FellVascular Biology Program and the Department of Surgery. Boston Children's Hospital, Boston, Massachusetts, USA.
Mark PuderVascular Biology Program and the Department of Surgery. Boston Children's Hospital, Boston, Massachusetts, USA.
Kathleen M GuraDepartment of Pharmacy, Boston Children's Hospital, Boston, Massachusetts, USA Kathleen.Gura@childrens.harvard.edu.
Boston Children's Hospital · US

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
Generation and use of lipid emulsions to understand mechanisms of and optimally manage parenteral nutrition associated liver diseaseF32DK104525 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI FELL, GILLIAN LYNAPP · 2014 to 2016
$163k
NHLBI NIH HHS T32 HL007734NIDDK NIH HHS F32 DK104525
6 · The paper itself

Abstract

Intravenous fat emulsions (IVFEs) provide essential fatty acids (EFAs) and are a dense source of energy in parenteral nutrition (PN). Parenterally administered lipid was introduced in the 17th century but plagued with side effects. The formulation of IVFEs later on made it a relatively safe component for administration to patients. Many ingredients are common to all IVFEs, yet the oil source(s) and its (their) percentage(s) makes them different from each other. The oil used dictates how IVFEs are metabolized and cleared from the body. The fatty acids (FAs) present in each type of oil provide unique beneficial and detrimental properties. This review provides an overview of IVFEs and discusses factors that would help clinicians choose the optimal product for their patients.

Indexed as

AdultChildFat Emulsions, IntravenousFatty Acids, EssentialFish OilsHumansOlive OilParenteral NutritionPlant OilsSoybean OilFat Emulsions, IntravenousFatty Acids, EssentialFish OilsOlive OilPlant OilsSoybean Oilfatty acidsintravenous fat emulsionslipidsparenteral nutrition

Identifiers

PMID27533942
PMCPMC5438313
OpenAlexW2508698069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.