ArticleBioengineered2017
Immunosuppressive effect of extracts from leaves of Fraxinus Mandshurica Rupr.
Article in Bioengineered, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative Analysis of Chloroplast Genomes Reveals Molecular Evolution and Phylogenetic Relationships inInternational journal of molecular sciences · 2026Article
- Drought tolerance evaluation of Fraxinus mandshurica in a semi-arid area.BMC plant biology · 2025Article
- Predicting Heterosis and Selecting Superior Families and Individuals inPlants (Basel, Switzerland) · 2025Article
- Calceolarioside A, a Phenylpropanoid Glycoside fromMolecules (Basel, Switzerland) · 2022Article
- Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling.Molecules (Basel, Switzerland) · 2022Article
- Anti-Obesity and Gut Microbiota Modulation Effect of Secoiridoid-Enriched Extract fromMolecules (Basel, Switzerland) · 2020Article
- Comparative Studies ofPlants (Basel, Switzerland) · 2020Article
- Cytotoxic and apoptotic potential ofBioengineered · 2019Article
- Molecular cloning and functional analysis of 4-Coumarate:CoA ligase 4(4CL-like 1)from Fraxinus mandshurica and its role in abiotic stress tolerance and cell wall synthesis.BMC plant biology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants provide a rich resource of medicinal material for research and development of new medicine. To discover new compounds as Immunosuppressant from plants, we evaluated the immunosuppressive effect of different fractions and particularly one compound (Calceolarioside A) that were extracted from the leaves of Fraxinus Mandshurica Rupr. The fractions and the compound were tested on the ability to reduce Immunoglobulin E (IgE) secretion by human U266 multiple myeloma cells (U266 cells) and to reduce interleukin-2 (IL-2) secretion by mouse spleen cells. Our results showed that both the butanol extract fraction and the compound of Calceolarioside A inhibited the IgE and IL-2 production in U266 cells and mouse spleen cells respectively, and no cytotoxicity was observed within the effective dose range. These results suggest that Calceolarioside A could potentially serve as an immunosuppressant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.