Asthma and diabetes: Does treatment with metformin improve asthma?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Association of Metformin Use with Asthma Exacerbation in Patients with Concurrent Asthma and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies.Canadian respiratory journal · 2020 · on this map
   Pooled it
2. Metformin for asthma exacerbations.The Cochrane database of systematic reviews · 2026
   Article
3. Metabolic Medications and Youth Hospitalizations for Asthma: A Pre-Post Quasi-Experimental Study.CHEST pulmonary · 2025
   Article
4. Metformin effects on respiratory and metabolic outcomes in asthma and metabolic syndrome: a double-blind, randomized, placebo-controlled clinical trial.Annals of medicine and surgery (2012) · 2025
   Article
5. Non-T2 asthma.Current opinion in pulmonary medicine · 2025
   Review
6. Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma.Paediatric drugs · 2023
   Review
7. Metabolic Contributions to Pathobiology of Asthma.Metabolites · 2023
   Review
8. SARS-CoV-2 infection and diabetes: Pathophysiological mechanism of multi-system organ failure.World journal of virology · 2022
   Review
9. Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
   Article
10. The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort.BMC medicine · 2019
    Article
11. Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin.Respirology (Carlton, Vic.) · 2019
    Article

Corrections and comments

• Comment on
  Metformin use and asthma outcomes among patients with concurrent asthma and diabetes.2016

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as