Evidence map›Paper›PMID 27533245›Full record

ArticleOncotarget2016

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

Shalaka S Hampras, Lara E Sucheston-Campbell, Rikki Cannioto, Jenny Chang-Claude, Francesmary Modugno, Thilo Dörk, Peter Hillemanns, Leah Preus, Keith L Knutson, Paul K Wallace and 160 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
    Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

170 authors at 20 institutions in 15 countries.

Shalaka S HamprasDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Lara E Sucheston-CampbellCollege of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Rikki CanniotoDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Francesmary ModugnoDepartment of Epidemiology and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Peter HillemannsClinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Leah PreusDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Keith L KnutsonDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Paul K WallaceDepartment of Flow & Image Cytometry, Roswell Park Cancer Institute, Buffalo, New York, USA.
Chi-Chen HongDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Grace FrielDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Warren DavisDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Mary NeslineCenter for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Linda E KelemenAlberta Health Services-Cancer Care, Department of Population Health Research, Calgary, Alberta, Canada.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Elisa V BanderaCancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Kathryn L TerryObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Nils SchoofDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kevin H EngDepartment of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
Alyssa ClayDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Prashant K SinghDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Janine M JosephDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Katja K H AbenDepartment for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands.
Hoda Anton-CulverDepartment of Epidemiology and School of Medicine, University of California Irvine, Irvine, California, USA.
Natalia AntonenkovaByelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus.
Helen BakerDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Yukie BeanDepartment of Obstetrics & Gynecology and Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Natalia BogdanovaGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Ralf ButzowDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Ian G CampbellCancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia.
Karen CartyCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Daniel W CramerObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Joe DennisDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Evelyn DespierreDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium.
Ed DicksDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Jennifer A DohertyDepartment of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Andreas du BoisDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
Matthias DürstDepartment of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Doug EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Diana EcclesWessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.
Robert P EdwardsDepartment of Obstetrics, Gynecology & Reproductive Sciences and Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Peter A FaschingDepartment of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, USA.
Brooke L FridleyDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA,.
Yu-Tang GaoShanghai Cancer Institute, Shanghai, China.
Aleksandra Gentry-MaharajInstitute for Women's Health, Population Health Sciences, University College - London, London, United Kingdom.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Rosalind GlasspoolCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
Jacek GronwaldInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Patricia HarringtonDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
Hanis Nazihah HasmadCancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
Michelle A T HildebrandtDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Claus HogdallDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Estrid HogdallInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
Satoyo HosonoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Edwin S IversenDepartment of Statistical Science, Duke University, Durham, North Carolina, USA.
Anna JakubowskaInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Melissa KellarDepartment of Obstetrics & Gynecology and Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Joseph L KelleyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lambertus A KiemeneyDepartment for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands.
Rüdiger KlapdorGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Nonna KolomeyevskayaDivision of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Camilla KrakstadDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Susanne K KjaerDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bridget KruszkaDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Jolanta KupryjanczykDepartment of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Diether LambrechtsVesalius Research Center, VIB, Leuven, Belgium,.
Sandrina LambrechtsDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
Alice W LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Shashikant LeleDivision of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Arto LeminenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Song LiuDepartment of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
Karen LuDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jan LubinskiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Lene LundvallDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Keitaro MatsuoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Valeria McGuireDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
John R McLaughlinProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Ian McNeishInstitute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Usha MenonWomen's Cancer, UCL EGA Institute for Women's Health, London, UK.
Joanna Moes-SosnowskaDepartment of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Steven A NarodWomen's College Research Institute, Toronto, Ontario, Canada.
Lotte NedergaardDepartment of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Stefan NickelsGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA,.
Rachel Palmieri WeberDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
James PaulCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
Tanja PejovicDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Barbara PerkinsDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Jenny Permuth-WeyDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Malcolm C PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Joanna Plisiecka-HalasaDepartment of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Mary Anne RossingProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Joseph H RothsteinDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Anja RudolphGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Ingo B RunnebaumDepartment of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Iwona K RzepeckaDepartment of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Eva SchernhammerDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Kristina SchmittDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Ira SchwaabInstitut für Humangenetik Wiesbaden, Wiesbaden, Germany.
Xiao-Ou ShuVanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yurii B ShvetsovCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, Scotland, UK.
Weiva SiehDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Honglin SongDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Melissa C SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, Australia.
Ingvild L TangenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Soo-Hwang TeoCancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia,.
Pamela J ThompsonCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Agnieszka TimorekDepartment of Obstetrics, Gynecology and Oncology, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
Ya-Yu TsaiDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Shelley S TworogerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jonathan TyrerDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Anna M van AltenaDepartment of Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Ignace VergoteDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium.
Robert A VierkantDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Christine WalshWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Shan Wang-GohrkeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Kristine G WicklundProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yin-Ling WooDepartment of Obstetrics and Gynaecology, Affiliated with UM Cancer Research Institute, Faculty of Medicine, University of Malaya, Malaysia.
Hannah YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Wei ZhengVanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Argyrios ZiogasDepartment of Epidemiology and School of Medicine, University of California Irvine, Irvine, California, USA.
Simon A GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Joellen M SchildkrautDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Paul P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Roberta B NessSchool of Public Health, The University of Texas, Houston, Texas, USA.
Kunle OdunsiDivision of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Ellen L GoodeDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Roswell Park Comprehensive Cancer Center · USStanford University · USRadboud University Nijmegen · NLLondon Women's Clinic · GBLunenfeld-Tanenbaum Research Institute · CAUniversity College London · GBMount Sinai Hospital · CAWomen's College Hospital · CAUniversity of Glasgow · GBRadboud University Medical Center · NLUniversity of Cambridge · GBCedars-Sinai Medical Center · USMedizinische Hochschule Hannover · DEMemorial Sloan Kettering Cancer Center · USUniversity of Southern California · USBC Cancer Agency · CABeatson West of Scotland Cancer Centre · GBDanish Cancer Society · DKDivision of Cancer Epidemiology and GeneticsHarvard University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 15960Cancer Research UK 16561Medical Research Council G0501974NCATS NIH HHS UL1 TR001863NCI NIH HHS K07 CA080668NCI NIH HHS K07 CA092044NCI NIH HHS K07 CA095666NCI NIH HHS K07 CA143047NCI NIH HHS K22 CA138563NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA072720NCI NIH HHS P30 CA168524NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063682NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA074850NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA080742NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA087696NCI NIH HHS R01 CA106414NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA114343NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA136924NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA168758NCI NIH HHS R01 CA188900NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA058860NCI NIH HHS U01 CA069417NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA186107NCRR NIH HHS M01 RR000056NIEHS NIH HHS T32 ES013678NIGMS NIH HHS P20 GM103418NIGMS NIH HHS R21 GM086689NLM NIH HHS K01 LM012100
6 · The paper itself

Abstract

backgroundRegulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.

methodsIn a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.

resultsThe most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).

conclusionsCommon inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.

Indexed as

Polymorphism, Single NucleotideAdenocarcinoma, Clear CellAdultAgedCarcinoma, Ovarian EpithelialFemaleGene Expression Regulation, NeoplasticGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMiddle AgedNeoplasms, Glandular and EpithelialOvarian NeoplasmsProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IIbiomarkersgenetic variationimmunosuppressionovarian cancerTGFBR2

Identifiers

PMID27533245
PMCPMC5340115
OpenAlexW2463107397

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.