ArticleEmerging infectious diseases2016
Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands.
Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Seroprevalence of coxsackievirus A6 and enterovirus A71 infection in humans: a systematic review and meta-analysis.Archives of virology · 2023Pooled it
- Article
- Advances in anti-EV-A71 drug development research.Journal of advanced research · 2024Review
- Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019-2021.Biosafety and health · 2023Article
- A five-year retrospective study on the epidemiology of hand, foot and mouth disease in Sabah, Malaysia.Scientific reports · 2021Article
- Seroprevalence and Virologic Surveillance of Enterovirus 71 and Coxsackievirus A6, United Kingdom, 2006-2017.Emerging infectious diseases · 2021Review
- First seroepidemiological investigation of human enterovirus 71 in Iran.Iranian journal of microbiology · 2021Article
- Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.Emerging infectious diseases · 2021Article
- Article
- Phylogenetic characteristics and molecular epidemiological analysis of novel enterovirus EV-B83 isolated from Tibet, China.Scientific reports · 2020Article
- Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017.BMC infectious diseases · 2019Article
- A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence.Scientific reports · 2019Article
- Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.Emerging microbes & infections · 2018Article
- Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.Emerging microbes & infections · 2018Article
- Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children.Nature communications · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outbreaks of human enterovirus 71 (EV-71) in Asia are related to high illness and death rates among children. To gain insight into the potential threat for the population of Europe, we determined the neutralizing activity in intravenous immunoglobulin (IVIg) batches and individual serum samples from donors in the Netherlands against EV-71 strains isolated in Europe and in Asia. All IVIg batches and 41%, 79%, and 65% of serum samples from children ≤5 years of age, women of childbearing age, and HIV-positive men, respectively, showed high neutralizing activity against a Dutch C1 strain, confirming widespread circulation of EV-71 in the Netherlands. Asian B3-4 and C4 strains were efficiently cross-neutralized, predicting possible protection against extensive circulation and associated outbreaks of those types in Europe. However, C2 and C5 strains that had few mutations in the capsid region consistently escaped neutralization, emphasizing the importance of monitoring antigenic diversity among circulating EV-71 strains.
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