ArticleImmunity2016
Cytosolic DNA Sensing: The Field Narrows.
Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair.Nature biomedical engineering · 2024Article
- Non-viral targeted insertion of large payloads into T cells.Nature biomedical engineering · 2024Article
- Hunting down the elusive cytosolic-DNA sensor.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Type I interferon pathway in pediatric systemic lupus erythematosus.World journal of pediatrics : WJP · 2024Review
- Cellular functions of eukaryotic RNA helicases and their links to human diseases.Nature reviews. Molecular cell biology · 2023Review
- Role of cGAS-STING signaling pathway in cardiometabolic diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Regulation of cGAS activity by RNA-modulated phase separation.EMBO reports · 2023Article
- Entanglement of Methylation Changes and cGAS-STING Signaling in Non-Small-Cell Lung Cancer.Combinatorial chemistry & high throughput screening · 2023Article
- Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis.Journal of neuroinflammation · 2022Review
- Lupus Nephritis: Current Perspectives and Moving Forward.Journal of inflammation research · 2022Review
- Classes of therapeutics to amplify the immune response.Breast cancer research and treatment · 2022Review
- Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.Molecular cancer therapeutics · 2021Article
- Polyvalent design in the cGAS-STING pathway.Seminars in immunology · 2021Review
- Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons.Cells · 2021Article
- Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion.Frontiers in microbiology · 2021Review
- Crosstalk between cGAS-STING signaling and cell death.Cell death and differentiation · 2020Review
- cGAS-STING pathway in oncogenesis and cancer therapeutics.Oncotarget · 2020Review
- Inflammatory microenvironment remodelling by tumour cells after radiotherapy.Nature reviews. Cancer · 2020Review
- The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA.Frontiers in immunology · 2020Review
- How Retroviruses and Retrotransposons in Our Genome May Contribute to Autoimmunity in Rheumatological Conditions.Frontiers in immunology · 2020Review
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
The innate response to many pathogens involves type I interferon production that is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial. In this issue of Immunity, Gray et al. (2016) use genetics to bring some much-needed clarity to the field.
Indexed as
Identifiers
27533006What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.