Evidence map›Paper›PMID 27532897›Full record

ArticleAJR. American journal of roentgenology2016

Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment.

Hiroyuki Abe, Naoko Mori, Keiko Tsuchiya, David V Schacht, Federico D Pineda, Yulei Jiang, Gregory S Karczmar

Registry-linked trialAbstract read
In one paragraph

Article in AJR. American journal of roentgenology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04341129 (Abbreviated MRI Protocol), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04341129 early_phase1completednot on this mapstarted 2020, after this paper: background citation

Abbreviated MRI Protocol: Initial Experience With Dotarem® (Gadoterate Meglumine)

TypeinterventionalSponsorUniversity of ChicagoRan2020 to 2023Enrolled50ConditionsBreast Neoplasms, Breast Diseases, Breast Fibroadenoma, Breast CancerArmsAbbreviated MRI protocol: initial experience with Dotarem® (Gadoterate Meglumine)
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Abbreviated and Ultrafast Dynamic Contrast-enhanced (DCE) MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  10. Ultrafast Breast MRI: A Narrative Review.Journal of personalized medicine · 2025
    Review
  11. Observational
  12. Article
  13. Article
  14. Advances in Risk Management and Screening for Women at Increased Risk of Breast Cancer: The Role of MR Imaging and Personalised Approaches.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  15. Article
  16. Updates in Breast Cancer Screening and Diagnosis.Current treatment options in oncology · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroyuki Abe1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
Naoko Mori2 Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Keiko Tsuchiya1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
David V Schacht1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
Federico D Pineda1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
Yulei Jiang1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
Gregory S Karczmar1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
Variation in Hormone and xenobiotic metabolizing enzyme genes and breast cancerP50CA125183 · NCI · UNIVERSITY OF CHICAGO · PI COX, NANCY · 2006 to 2010
$11.3M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
Breast Cancer Screening with Quantitative Ultra-Fast DCEMRI and Clinical Risk AssessmentR01CA218700 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S. · 2017 to 2021
$3.0M
Assessment of Breast Cancer Risk with High Spectral and Spatial Resolution MRIR01CA167785 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S., NEWSTEAD, GILLIAN · 2013 to 2017
$2.4M
Quantitative DCEMRI of Prostate Cancer Correlation with Gold StandardsR01CA172801 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S., OTO, AYTEKIN · 2013 to 2017
$2.3M
MRI of Early Non-invasive Rodent Mammary CancersR01CA133490 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S. · 2011 to 2015
$1.6M
NCI NIH HHS P30 CA014599NCI NIH HHS P50 CA125183NCI NIH HHS R01 CA133490NCI NIH HHS R01 CA172801NCI NIH HHS R01 CA218700NCI NIH HHS U01 CA142565
6 · The paper itself

Abstract

objectiveThe purposes of this study were to evaluate diagnostic parameters measured with ultrafast MRI acquisition and with standard acquisition and to compare diagnostic utility for differentiating benign from malignant lesions. MATERIALS AND

methodsUltrafast acquisition is a high-temporal-resolution (7 seconds) imaging technique for obtaining 3D whole-breast images. The dynamic contrast-enhanced 3-T MRI protocol consists of an unenhanced standard and an ultrafast acquisition that includes eight contrast-enhanced ultrafast images and four standard images. Retrospective assessment was performed for 60 patients with 33 malignant and 29 benign lesions. A computer-aided detection system was used to obtain initial enhancement rate and signal enhancement ratio (SER) by means of identification of a voxel showing the highest signal intensity in the first phase of standard imaging. From the same voxel, the enhancement rate at each time point of the ultrafast acquisition and the AUC of the kinetic curve from zero to each time point of ultrafast imaging were obtained.

resultsThere was a statistically significant difference between benign and malignant lesions in enhancement rate and kinetic AUC for ultrafast imaging and also in initial enhancement rate and SER for standard imaging. ROC analysis showed no significant differences between enhancement rate in ultrafast imaging and SER or initial enhancement rate in standard imaging.

conclusionUltrafast imaging is useful for discriminating benign from malignant lesions. The differential utility of ultrafast imaging is comparable to that of standard kinetic assessment in a shorter study time.

Indexed as

AdultAgedBreast NeoplasmsContrast MediaDiagnosis, DifferentialFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMeglumineMiddle AgedOrganometallic CompoundsRetrospective StudiesContrast Mediagadobenic acidMeglumineOrganometallic CompoundsbreastcancerkineticsMRIultrafast

Identifiers

PMID27532897
PMCPMC6535046

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.