ArticleNeuroreport2016
Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder.
Article in Neuroreport, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome.Psychological medicine · 2023Trial
- The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Trial
- A Pivotal Response Treatment Package for Children With Autism Spectrum Disorder: An RCT.Pediatrics · 2019Trial
- Structural Brain Imaging Biomarkers of Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- Abnormal visual attention to simple social stimuli in 4-month-old infants at high risk for Autism.Scientific reports · 2021Article
- Investigating Changes in Reward-Related Neural Correlates After PEERS Intervention in Adolescents With ASD: Preliminary Evidence of a "Precision Medicine" Approach.Frontiers in psychiatry · 2021Article
- Increased Neural Reward Responsivity in Adolescents with ASD after Social Skills Intervention.Brain sciences · 2020Article
- Autism spectrum disorder.Nature reviews. Disease primers · 2020Review
- Circuits for social learning: A unified model and application to Autism Spectrum Disorder.Neuroscience and biobehavioral reviews · 2019Review
- Atypical longitudinal development of functional connectivity in adolescents with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2019Article
- Neurodevelopmental Disorders Affecting Sociability: Recent Research Advances and Future Directions in Autism Spectrum Disorder and Williams Syndrome.Current neurology and neuroscience reports · 2018Review
- Neural mechanisms of behavioral change in young adults with high-functioning autism receiving virtual reality social cognition training: A pilot study.Autism research : official journal of the International Society for Autism Research · 2018Article
- Biomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health.Focus (American Psychiatric Publishing) · 2018Review
- Magnetization-prepared shells trajectory with automated gradient waveform design.Magnetic resonance in medicine · 2018Article
- An agenda for 21st century neurodevelopmental medicine: lessons from autism.Revista de neurologia · 2018Article
- Pivotal response treatment for autism spectrum disorder: current perspectives.Neuropsychiatric disease and treatment · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Behavioral interventions for autism have gained prominence in recent years; however, the neural-systems-level targets of these interventions remain poorly understood. We use a novel Bayesian framework to extract network-based differences before and after a 16-week pivotal response treatment (PRT) regimen. Our results suggest that the functional changes induced by PRT localize to the posterior cingulate and are marked by a shift in connectivity from the orbitofrontal cortex to the occipital-temporal cortex. Our results illuminate a potential PRT-induced learning mechanism, whereby the neural circuits involved during social perception shift from sensory and attentional systems to higher-level object and face processing areas.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.