ReviewThe American journal of drug and alcohol abuse2017
Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse.
Review in The American journal of drug and alcohol abuse, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA.Frontiers in psychiatry · 2022Pooled it
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- Co-Use of Some Substances Associated With Higher Doses in Adolescents: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- [Nicotine consumption in childhood and adolescence-fundamentals and considerations for handling the topic in child and adolescent psychiatric settings].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Article
- The prevalence of smartphone, nicotine, and alcohol addiction among university students with temporomandibular disorders.BMC oral health · 2026Article
- Oral administration of crocin significantly alleviated anxiety, and depressive-like behavior following ethanol and nicotine abstinence in adolescent male rats.Scientific reports · 2025Article
- Real-Time Antecedents of Young Adults' Vaping and Co-Vaping of Nicotine and Cannabis: An Ecological Momentary Assessment Study.Journal of medical Internet research · 2025Article
- Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats.Neuropharmacology · 2025Article
- It's Not Just Black and White: Identifying the Combined Influence of Multilevel Determinants of Tobacco Use Among Black Adolescents.Journal of studies on alcohol and drugs · 2024Article
- A cross-sectional assessment of the influence of information sources about substance use in adolescents' tobacco prevalence.Heliyon · 2024Article
- Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.The international journal of neuropsychopharmacology · 2024Article
- Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues.Scientific reports · 2024Article
- Combustible cigarette smokers versus e-cigarette dual users among Latinx individuals: Differences in alcohol and drug use severity.Experimental and clinical psychopharmacology · 2024Article
- Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis.International journal of preventive medicine · 2024Article
- Article
- Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans.Drug and alcohol dependence · 2023Article
- The co-use of nicotine and prescription psychostimulants: A review of their behavioral and neuropharmacological interactions.Drug and alcohol dependence · 2023Review
- Behavioural risk patterns in adolescents with excess weight participating in the PRALIMAP-INÈS trial.Public health nutrition · 2023Article
- The situational contexts and subjective effects of co-use of electronic cigarettes and alcohol among college students: An ecological momentary assessment (EMA) study.Drug and alcohol dependence · 2022Article
- Are Health Literacy and Physical Literacy Independent Concepts? A Gender-Stratified Analysis in Medical School Students from Croatia.Children (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Concurrent use of tobacco and alcohol or psychostimulants represents a major public health concern, with use of one substance influencing consumption of the other. Co-abuse of these drugs leads to substantial negative health outcomes, reduced cessation, and high economic costs, but the underlying mechanisms are poorly understood. Epidemiological data suggest that tobacco use during adolescence plays a particularly significant role. Adolescence is a sensitive period of development marked by major neurobiological maturation of brain regions critical for reward processing, learning and memory, and executive function. Nicotine exposure during this time produces a unique and long-lasting vulnerability to subsequent substance use, likely via actions at cholinergic, dopaminergic, and serotonergic systems. In this review, we discuss recent clinical and preclinical data examining the genetic factors and mechanisms underlying co-use of nicotine and alcohol or cocaine and amphetamines. We evaluate the critical role of nicotinic acetylcholine receptors throughout, and emphasize the dearth of preclinical studies assessing concurrent drug exposure. We stress important age and sex differences in drug responses, and highlight a brief, low-dose nicotine exposure paradigm that may better model early use of tobacco products. The escalating use of e-cigarettes among youth necessitates a closer look at the consequences of early adolescent nicotine exposure on subsequent alcohol and drug abuse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.