ArticleEpilepsy & behavior : E&B2016
Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory.
Article in Epilepsy & behavior : E&B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychological Deficits in Disordered Screen Use Behaviours: A Systematic Review and Meta-analysis.Neuropsychology review · 2024Pooled it
- Neuropsychological profile and social cognition in children and adolescents with temporal lobe epilepsy.Epilepsia open · 2026Article
- The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Article
- Cognitive reorganization in patients with Parkinson's Disease and Mild Cognitive Impairment: a neuropsychological network approach.Scientific reports · 2024Article
- Unveiling the cognitive network organization through cognitive performance.Scientific reports · 2024Article
- Brain tumor-related epilepsy: an overview on neuropsychological, behavioral, and quality of life issues and assessment methodology.Frontiers in neurology · 2024Review
- Visuo-Spatial Working Memory and Mathematical Skills in Children: A Network Analysis Study.Behavioral sciences (Basel, Switzerland) · 2023Article
- Brain language networks and cognitive outcomes in children with frontotemporal lobe epilepsy.Frontiers in human neuroscience · 2023Article
- Neuropsychological networks in cognitively healthy older adults and dementia patients.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- Presurgical cognitive status in patients with low-grade glioma and epilepsy: Testing the effects of seizures, antiseizure medications, and tumor localization.Brain and behavior · 2022Article
- Reward-based decision-making in mesial temporal lobe epilepsy patients with unilateral hippocampal sclerosis pre- and post-surgery.NeuroImage. Clinical · 2022Article
- Exploring the Complexity of Aphasia With Network Analysis.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Network topology of the cognitive phenotypes of temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- A Graph Theory Approach to Clarifying Aging and Disease Related Changes in Cognitive Networks.Frontiers in aging neuroscience · 2021Article
- Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol.Frontiers in human neuroscience · 2021Article
- Reconfiguration dynamics of a language-and-memory network in healthy participants and patients with temporal lobe epilepsy.NeuroImage. Clinical · 2021Article
- Article
- Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.Frontiers in neuroanatomy · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveNormal cognitive function is defined by harmonious interaction among multiple neuropsychological domains. Epilepsy has a disruptive effect on cognition, but how diverse cognitive abilities differentially interact with one another compared with healthy controls (HC) is unclear. This study used graph theory to analyze the community structure of cognitive networks in adults with temporal lobe epilepsy (TLE) compared with that in HC.
methodsNeuropsychological assessment was performed in 100 patients with TLE and 82 HC. For each group, an adjacency matrix was constructed representing pair-wise correlation coefficients between raw scores obtained in each possible test combination. For each cognitive network, each node corresponded to a cognitive test; each link corresponded to the correlation coefficient between tests. Global network structure, community structure, and node-wise graph theory properties were qualitatively assessed.
resultsThe community structure in patients with TLE was composed of fewer, larger, more mixed modules, characterizing three main modules representing close relationships between the following: 1) aspects of executive function (EF), verbal and visual memory, 2) speed and fluency, and 3) speed, EF, perception, language, intelligence, and nonverbal memory. Conversely, controls exhibited a relative division between cognitive functions, segregating into more numerous, smaller modules consisting of the following: 1) verbal memory, 2) language, perception, and intelligence, 3) speed and fluency, and 4) visual memory and EF. Overall node-wise clustering coefficient and efficiency were increased in TLE. SIGNIFICANCE: Adults with TLE demonstrate a less clear and poorly structured segregation between multiple cognitive domains. This panorama suggests a higher degree of interdependency across multiple cognitive domains in TLE, possibly indicating compensatory mechanisms to overcome functional impairments.
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