Trial reportJournal of acquired immune deficiency syndromes (1999)2017
Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.
Abstract readClinical Trial
In one paragraph
Trial report in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Association Between Different Levels of Suppressed Viral Load and the Risk of Sexual Transmission of HIV Among Serodiscordant Couples on Antiretroviral Therapy: A Systematic Review.AIDS and behavior · 2026Pooled it
- HIV continuum of care: expanding scope beyond a cross-sectional view to include time analysis: a systematic review.BMC public health · 2021Pooled it
- Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Pooled it
- Direct-Acting Antivirals Quickly Eradicate Hepatitis C Virus From the Liver in People With Human Immunodeficiency Virus but Do Not Fully Reverse Immune Activation.The Journal of infectious diseases · 2025Trial
- Virologic outcomes in early antiretroviral treatment: HPTN 052.HIV clinical trials · 2017Trial
- HIV biomedical prevention knowledge, attitudes, and behaviors among U.S. women enrolled in a longitudinal cohort study 2014-2019.BMC public health · 2025Article
- Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China.BMC public health · 2025Article
- Article
- HIV and intersectional stigma among people living with HIV and healthcare workers and antiretroviral therapy adherence in the Dominican Republic.International journal of STD & AIDS · 2024Article
- Characterizing the Communication Networks of Spanish- and English-Speaking Latinx Sexual Minority Men and Their Roles in Pre-Exposure Prophylaxis Uptake.Journal of health communication · 2024Article
- Genetic network analysis of human immunodeficiency virus sexual transmission in rural Southwest China after the expansion of antiretroviral therapy: A population-based study.Frontiers in microbiology · 2022Article
- Article
- A cluster randomized trial to reduce HIV risk from outside partnerships in Zambian HIV-Negative couples using a novel behavioral intervention, "Strengthening Our Vows": Study protocol and baseline data.Contemporary clinical trials communications · 2021Article
- Development and Validation of a Sociodemographic and Behavioral Characteristics-Based Risk-Score Algorithm for Targeting HIV Testing Among Adults in Kenya.AIDS and behavior · 2021Article
- Evaluation of Phylogenetic Methods for Inferring the Direction of Human Immunodeficiency Virus (HIV) Transmission: HIV Prevention Trials Network (HPTN) 052.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Depression and HIV Transmission Risk among Methamphetamine-Using Men who have Sex with Men.Addiction research & theory · 2021Article
- Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Phylogenetic Analysis of Human Immunodeficiency Virus from People Who Inject Drugs in Indonesia, Ukraine, and Vietnam: HPTN 074.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- ART uptake and adherence among women who use drugs globally: A scoping review.Drug and alcohol dependence · 2020Article
- Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging.The Analyst · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Susan H Eshleman*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Sarah E Hudelson
Andrew D Redd
Ronald Swanstrom
San-San Ou
Xinyi Cindy Zhang
Li-Hua Ping
Estelle Piwowar-Manning
Stephen F Porcella
Matthew F Sievers
Craig A Martens
Daniel Bruno
Elena Dukhovlinova
Marybeth McCauley
Theresa Gamble
Jessica M Fogel
Devin Sabin
Thomas C Quinn
Laurence Gunde
Madalitso Maliwichi
Nehemiah Nhando
Victor Akelo
Sikhulile Moyo
Ravindre Panchia
Nagalingeswaran Kumarasamy
Nuntisa Chotirosniramit
Marineide Gonçalves de Melo
Jose Pilotto
Beatriz Grinsztejn
Kenneth Mayer
Ying Q Chen
James P Hughes
Myron S Cohen
Funding
LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5MSDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9MInfectious Diseases Research Technologies Core - RMLZICAI001052 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$133.3MLC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MUniversity of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit 2024 SupplementUM1AI069423 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, MINA CHRISTINE HOSSEINIPOUR · 2012 to 2026
$71.8MUCLA AIDS Prevention and Treatment Clinical Trials UnitUM1AI069424 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith S. Currier, RAPHAEL J LANDOVITZ · 2012 to 2026
$51.8MSoweto Clinical Trials UnitUM1AI069453 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI Glenda E Gray, Lerato Mohapi · 2012 to 2026
$40.9MBotswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU Y18 SupplementUM1AI069456 · NIAID · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2012 to 2026
$29.4MThe FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)UM1AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI BEATRIZ GRINSZTEJN · 2012 to 2026
$26.3MInternational Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8MBiological properties of HIV-1 V3 evolutionary variantsR37AI044667 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SWANSTROM, RONALD I · 2005 to 2014
$3.4MNIAID NIH HHS P30 AI050410NIAID NIH HHS R37 AI044667NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI069423NIAID NIH HHS UM1 AI069424NIAID NIH HHS UM1 AI069453NIAID NIH HHS UM1 AI069456NIAID NIH HHS UM1 AI069476
Abstract
HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
Indexed as
Anti-HIV AgentsChemopreventionCohort StudiesDisease Transmission, InfectiousFemaleHIV InfectionsHumansMaleTreatment OutcomeAnti-HIV Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.