Evidence map›Paper›PMID 27532060›Full record

ArticleAnnual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference2013

Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy.

Chanchala D Kaddi, May D Wang

Abstract read
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In one paragraph

Article in Annual ORNL Biomedical Science and Engineering Center Conference. ORNL Biomedical Science and Engineering Center Conference, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chanchala D KaddiDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.
May D WangDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA (phone: 404-385-5059).

Funding

Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI SIMONS, JONATHAN W. · 2005 to 2009
$18.4M
Nanotechnology Linking Biomarkers with Cancer BehaviorR01CA108468 · NCI · EMORY UNIVERSITY · PI NIE, SHUMING · 2004 to 2008
$6.9M
NCI NIH HHS R01 CA108468NCI NIH HHS U54 CA119338
6 · The paper itself

Abstract

We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination effects of cooperation and drug treatment qualitatively match experimental observations from the literature.

Identifiers

PMID27532060
PMCPMC4983431

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.