ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Plasmodium Parasitemia Associated With Increased Survival in Ebola Virus-Infected Patients.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- The impact of malaria coinfection on Ebola virus disease outcomes: A systematic review and meta-analysis.PloS one · 2021Pooled it
- A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Pooled it
- Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia.The New England journal of medicine · 2017Trial
- Hookworm infection modulates lung and intestinal transcriptomic responses to SARS-CoV-2 in Syrian hamsters.Frontiers in immunology · 2025Article
- Viral haemorrhagic fevers and malaria co-infections among febrile patients seeking health care in Tanzania.Infectious diseases of poverty · 2022Article
- Malaria abrogates O'nyong-nyong virus pathologies by restricting virus infection in nonimmune cells.Life science alliance · 2022Article
- Association between oral antimalarial medication administration and mortality among patients with Ebola virus disease: a multisite cohort study.BMC infectious diseases · 2022Article
- Is malaria immunity a possible protection against severe symptoms and outcomes of COVID-19?Ghana medical journal · 2021Review
- Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers.Virology journal · 2021Article
- The COVID-19 Prevalence among Children: Hypotheses for Low Infection Rate and Few Severe Forms among This Age Group in Sub-Saharan Africa.Interdisciplinary perspectives on infectious diseases · 2021Review
- Sociodemographic and clinical determinants of in-facility case fatality rate for 938 adult Ebola patients treated at Sierra Leone Ebola treatment center.BMC infectious diseases · 2020Article
- Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection.Cell reports · 2020Article
- Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon.Emerging infectious diseases · 2020Article
- Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages.Viruses · 2019Article
- The Effect of Plasmodium on the Outcome of Ebola Virus Infection in a Mouse Model.The Journal of infectious diseases · 2018Article
- What treating Ebola means for pandemic influenza.Journal of public health policy · 2018Article
- When do co-infections matter?Current opinion in infectious diseases · 2018Review
- Food Insecurity as a Risk Factor for Outcomes Related to Ebola Virus Disease in Kono District, Sierra Leone: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2018Article
- Elimination of Falciparum Malaria and Emergence of Severe Dengue: An Independent or Interdependent Phenomenon?Frontiers in microbiology · 2018Article
- Insights from clinical research completed during the west Africa Ebola virus disease epidemic.The Lancet. Infectious diseases · 2017Review
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Authors and funding
41 authors at 10 institutions in 5 countries.
Funding
Abstract
backgroundThe ongoing Ebola outbreak in West Africa has resulted in 28 646 suspected, probable, and confirmed Ebola virus infections. Nevertheless, malaria remains a large public health burden in the region affected by the outbreak. A joint Centers for Disease Control and Prevention/National Institutes of Health diagnostic laboratory was established in Monrovia, Liberia, in August 2014, to provide laboratory diagnostics for Ebola virus.
methodsAll blood samples from suspected Ebola virus-infected patients admitted to the Médecins Sans Frontières ELWA3 Ebola treatment unit in Monrovia were tested by quantitative real-time polymerase chain reaction for the presence of Ebola virus and Plasmodium species RNA. Clinical outcome in laboratory-confirmed Ebola virus-infected patients was analyzed as a function of age, sex, Ebola viremia, and Plasmodium species parasitemia.
resultsThe case fatality rate of 1182 patients with laboratory-confirmed Ebola virus infections was 52%. The probability of surviving decreased with increasing age and decreased with increasing Ebola viral load. Ebola virus-infected patients were 20% more likely to survive when Plasmodium species parasitemia was detected, even after controlling for Ebola viral load and age; those with the highest levels of parasitemia had a survival rate of 83%. This effect was independent of treatment with antimalarials, as this was provided to all patients. Moreover, treatment with antimalarials did not affect survival in the Ebola virus mouse model.
conclusionsPlasmodium species parasitemia is associated with an increase in the probability of surviving Ebola virus infection. More research is needed to understand the molecular mechanism underlying this remarkable phenomenon and translate it into treatment options for Ebola virus infection.
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