Evidence map›Paper›PMID 27531684›Full record

ArticleHepatology (Baltimore, Md.)2017

Patient-reported barriers are associated with lower hepatocellular carcinoma surveillance rates in patients with cirrhosis.

Sherean Farvardin, Jaimin Patel, Maleka Khambaty, Olutola A Yerokun, Huram Mok, Jasmin A Tiro, Adam C Yopp, Neehar D Parikh, Jorge A Marrero, Amit G Singal

Abstract readComparative Study
In one paragraph

Article in Hepatology (Baltimore, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Financial Burden of Hepatocellular Carcinoma Screening in Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
    Trial
  4. Trial
  5. Multicenter Randomized Clinical Trial of a Mailed Outreach Strategy for Hepatocellular Carcinoma Surveillance.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Trial
  6. Novel Application of Predictive Modeling: A Tailored Approach to Promoting HCC Surveillance in Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Trial
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  8. Missed Diagnosis in Alcohol-Related Hepatocellular Carcinoma: A Call for Alcohol Consumption and Liver Disease Early Detection.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sherean FarvardinDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
Jaimin PatelDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
Maleka KhambatyDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
Olutola A YerokunDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
Huram MokDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
Jasmin A TiroHarold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX.
Adam C YoppHarold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX.
Neehar D ParikhDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
Jorge A MarreroDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
Amit G SingalDepartment of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.

Funding

UT Southwestern Center of Patient-Centered Outcomes Research (PCOR)R24HS022418 · AHRQ · UT SOUTHWESTERN MEDICAL CENTER · PI HALM, ETHAN A · 2013 to 2017
$5.0M
AHRQ HHS R24 HS022418
6 · The paper itself

Abstract

Over 20% of patients with cirrhosis are nonadherent with hepatocellular carcinoma (HCC) surveillance recommendations; however, few studies have evaluated the impact of patient-level factors on surveillance receipt. We characterized the association between HCC surveillance receipt and patient knowledge, attitudes, and perceived barriers in a racially diverse and socioeconomically disadvantaged cohort of patients with cirrhosis. Patients with cirrhosis followed at a large urban hospital were invited to complete a survey about HCC surveillance between August 2014 and December 2015. Multivariable logistic regression was performed to identify factors associated with HCC surveillance receipt during the 12-month period preceding and 6-month period after survey administration. We achieved a response rate of 71.8% (n = 541 of 753). Patients demonstrated high levels of HCC-related knowledge (summary score, 77.7%); however, 48.6% believed that eating a healthy diet precluded the need for HCC surveillance, and 34.0% believed that HCC surveillance was not necessary if they had a normal physical exam and/or lacked clinical symptoms. Patients expressed worry about developing and dying from HCC, but nearly half (49.9%) of patients reported barriers to receiving HCC surveillance, including difficulty with the scheduling process (30.5%), costs of surveillance testing (25.3%), and transportation difficulties (17.3%). HCC surveillance receipt was significantly higher in patients who knew cirrhosis is a risk factor for developing HCC (odds ratio [OR], 3.09; 95% confidence interval [CI], 1.25-7.62) and significantly lower in those reporting barriers to surveillance (OR, 0.42; 95% CI, 0.25-0.70).

conclusionPatients with cirrhosis are knowledgeable and interested in HCC surveillance; however, patient-reported barriers are associated with lower surveillance rates in clinical practice and represent potential intervention targets to improve HCC surveillance effectiveness. (Hepatology 2017;65:875-884).

Indexed as

Health Knowledge, Attitudes, PracticeAdultAttitude to HealthCarcinoma, HepatocellularEarly Detection of CancerEducational StatusFemaleHumansInsurance CoverageLiver CirrhosisLiver NeoplasmsMaleMiddle AgedPatient CompliancePopulation SurveillanceRacial Groups

Identifiers

PMID27531684
PMCPMC5568252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.