Evidence map›Paper›PMID 27531500›Full record

ReviewBehavioural brain research2018

Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury.

Ali Alawieh, Jing Zhao, Wuwei Feng

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Behavioural brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05706168 (A Study to Investigate the Effects of Aerobic Exercise Training), which is not on this map. Cited by 102 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 12 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05706168 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Study to Investigate the Effects of Aerobic Exercise Training (AET) on the Large Intracranial and Extracranial Cerebral Arteries and the Cognitive and Motor Functions in Post Stroke Patients.

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2023 to 2024Enrolled120ConditionsStrokeArmstreadmill exercise, Cycle ergometer exercise
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 12 syntheses or guidelines pooled it, 211 citations in OpenAlex.

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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ali AlawiehMedical Scientist Training Program, Medical University of South Carolina, Charleston, SC, 29425, USA.
Jing ZhaoMinhang District Central Hospital, Fudan University, Shanghai, 201199, China.
Wuwei FengDepartment of Neurology, MUSC Stroke Center, Medical University of South Carolina, Charleston, SC, 29425, USA; Department of Health Science and Research, The Center of Rehabilitation Science in Neurological Conditions, College of Health Professions, Medical University of South Carolina, Charleston, SC, 29425, USA. Electronic address: feng@musc.edu.
Medical University of South Carolina · USFudan University · CN

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2015 to 2024
$12.7M
NCATS NIH HHS UL1 TR001450NICHD NIH HHS P2C HD086844NIGMS NIH HHS P20 GM109040
6 · The paper itself

Abstract

Neurological disorders are a major cause of chronic disability globally among which stroke is a leading cause of chronic disability. The advances in the medical management of stroke patients over the past decade have significantly reduced mortality, but at the same time increased numbers of disabled survivors. Unfortunately, this reduction in mortality was not paralleled by satisfactory therapeutics and rehabilitation strategies that can improve functional recovery of patients. Motor recovery after brain injury is a complex, dynamic, and multifactorial process in which an interplay among genetic, pathophysiologic, sociodemographic and therapeutic factors determines the overall recovery trajectory. Although stroke recovery is the most well-studied form of post-injury neuronal recovery, a thorough understanding of the pathophysiology and determinants affecting stroke recovery is still lacking. Understanding the different variables affecting brain recovery after stroke will not only provide an opportunity to develop therapeutic interventions but also allow for developing personalized platforms for patient stratification and prognosis. We aim to provide a narrative review of major determinants for post-stroke recovery and their implications in other forms of brain injury.

Indexed as

Stroke RehabilitationAnimalsBrainHumansStrokeBrain injuryBrain recoveryNeurorehabilitationStroke recovery

Identifiers

PMID27531500
PMCPMC5305670
OpenAlexW2507953868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.