Evidence map›Paper›PMID 27531388›Full record

ArticleSocial cognitive and affective neuroscience2017

Impact of transcranial direct current stimulation on attentional bias for threat: a proof-of-concept study among individuals with social anxiety disorder.

Alexandre Heeren, Joël Billieux, Pierre Philippot, Rudi De Raedt, Chris Baeken, Philippe de Timary, Pierre Maurage, Marie-Anne Vanderhasselt

Registry-linked trialAbstract readControlled Clinical Trial
In one paragraph

Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06900959 (Transcranial Static Field Stimulation), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06900959 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Transcranial Static Field Stimulation (tSMS) and Transcranial Direct Current Stimulation (tDCS) for the Treatment of Neurological Symptoms

TypeinterventionalSponsorNeuromed IRCCSRan2025 to 2026Enrolled40ConditionsNeurological Diseases or ConditionsArmstranscranial static field stimulation (tSMS) and transcranial (tDCS)
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025
    Review
  11. Transcranial Electrical Stimulation: Clinical Implication and Practice for Treatment of Psychiatric Illness.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Review
  12. Article
  13. Review
  14. Trait-related neural basis of attentional bias to emotions: a tDCS study.Cognitive, affective & behavioral neuroscience · 2023
    Article
  15. Article
  16. Article
  17. Combinatorial approaches for treating neuropsychiatric social impairment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandre HeerenDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Joël BillieuxPsychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Pierre PhilippotPsychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Rudi De RaedtDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Chris BaekenDepartment of Psychiatry and Medical Psychology, Ghent University, Ghent, Belgium.
Philippe de TimaryPsychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Pierre MauragePsychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Marie-Anne VanderhasseltDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive models posit that social anxiety disorder (SAD) is associated with and maintained by attentional bias (AB) for social threat. However, over the last years, it has been suggested that AB in SAD may result from a decreased activation of the left prefrontal cortex, and particularly of its dorsolateral part (dlPFC). Accordingly, a transient increase of neural activity within the left dlPFC via non-invasive brain stimulation decreases AB in non-anxious control participants. Yet, none of these studies focused on SAD. This is especially unfortunate as SAD constitutes the main target for which a genuine reduction of AB may be most appropriate. In this experiment, we sought to investigate the causal influence of left dlPFC neuromodulation on AB among 19 female individuals with a DSM-5 diagnosis of SAD. We adopted a double-blind within-subject protocol in which we delivered a single-session of anodal versus sham transcranial Direct Current Stimulation (tDCS) over the left dlPFC during the completion of a probe discrimination task assessing AB. Consistent with our hypothesis, participants demonstrated a significant decrease in AB during the anodal tDCS over the left DLPFC relative to the sham stimulation. These findings value tDCS as an innovative procedure to gain new insight into the underlying mechanisms of SAD.

Indexed as

Transcranial Direct Current StimulationAdultArousalAttentional BiasDominance, CerebralDouble-Blind MethodFearFemaleHumansMalePhobia, SocialPrefrontal CortexYoung Adultattentional biasattention bias modificationneuromodulationprefrontal cortexsocial anxiety disordertranscranial direct current stimulation

Identifiers

PMID27531388
PMCPMC5390730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.