Evidence map›Paper›PMID 27531374›Full record

ArticleScientific reports2016

Safety and anti-hyperglycemic efficacy of various tea types in mice.

Manman Han, Guangshan Zhao, Yijun Wang, Dongxu Wang, Feng Sun, Jingming Ning, Xiaochun Wan, Jinsong Zhang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

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  19. Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking.Evidence-based complementary and alternative medicine : eCAM · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Manman HanState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Guangshan ZhaoState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Yijun WangState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Dongxu WangState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Feng SunState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Jingming NingState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Xiaochun WanState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Jinsong ZhangState Key Laboratory of Tea Plant Biology and Utilization, School of Tea &Food Science, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Anhui Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tea, a beverage consumed worldwide, has proven anti-hyperglycemic effects in animal models. Better efficacies of tea beverages are frequently associated with high-dose levels, whose safety attracts considerable attention. Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins. The present study aimed to assess various tea types for their safety properties and anti-hyperglycemic effects. Mice were allowed free access to tea infusion (1:30, w/v) for one week, and the rare smoked tea caused salient adverse reactions, including hepatic and gastrointestinal toxicities; meanwhile, the widely-consumed green and black teas, unlike the rare yellow tea, suppressed growth in fast-growing healthy mice. When mice were fed a high-fat diet and allowed free access to tea infusion (1:30, w/v) for 25 days, only yellow tea significantly reduced blood glucose. Therefore, various teas showed different safety profiles as well as anti-hyperglycemic efficacy strengths. To achieve an effective and safe anti-hyperglycemic outcome, yellow tea, which effectively suppressed high-fat diet-induced early elevation of hepatic thioredoxin-interacting protein, is an optimal choice.

Indexed as

TeaAnimalsBlood GlucoseCatechinDiet, High-FatFood SafetyHypoglycemic AgentsLiverMaleMetabolic SyndromeMiceMice, Inbred ICROxidation-ReductionRNABlood GlucoseCatechinHypoglycemic AgentsRNATea

Identifiers

PMID27531374
PMCPMC4987693
OpenAlexW2514027340

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.