Evidence map›Paper›PMID 27531196›Full record

ArticleMolecular diversity2016

Synthesis of new quinazolin-2,4-diones as anti-Leishmania mexicana agents.

Eduardo Enciso, Juan I Sarmiento-Sánchez, Héctor S López-Moreno, Adrián Ochoa-Terán, Ulises Osuna-Martínez, Evangelina Beltrán-López

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Synthesis of 3-(Pyridin-2-yl)quinazolin-2,4(1International journal of molecular sciences · 2023
    Article
  3. IRSC advances · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eduardo EncisoFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Blvd. de las Ámericas S/N, C.P. 80040, Culiacán Rosales, Sinaloa, Mexico.
Juan I Sarmiento-SánchezFacultad de Ingeniería Culiacán, Universidad Autónoma de Sinaloa, Blvd. de las Ámericas S/N, C.P. 80040, Culiacán Rosales, Sinaloa, Mexico. jsarmiento@uas.edu.mx.ORCID http://orcid.org/0000-0001-8961-4436
Héctor S López-MorenoFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Blvd. de las Ámericas S/N, C.P. 80040, Culiacán Rosales, Sinaloa, Mexico.
Adrián Ochoa-TeránCentro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Blvd. Alberto Limón Padilla S/N, Mesa de Otay, 22500, Tijuana, B.C., Mexico.
Ulises Osuna-MartínezFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Blvd. de las Ámericas S/N, C.P. 80040, Culiacán Rosales, Sinaloa, Mexico.
Evangelina Beltrán-LópezFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Blvd. de las Ámericas S/N, C.P. 80040, Culiacán Rosales, Sinaloa, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quinazolin-2,4-dione moiety is found in many compounds with important biological activities making it a target for its synthesis. In this work, a one-pot three-step synthesis of new quinazolin-2,4-diones from phthalic anhydrides and their activity against Leishmania mexicana are described. The new quinazolin-2,4-diones were isolated with yields in the range of 32-70 %. All compounds displayed lower cytotoxicity in RAW 264.7 macrophage over miltefosine. Compound 6,7-dichloro-3-phenylquinazoline-2,4(1H,3H)-dione (6e) displayed an attractive profile which includes anti-Leishmania mexicana activity ([Formula: see text] [Formula: see text]M), much lower cytotoxic activity ([Formula: see text] [Formula: see text]M) and a high selective index ([Formula: see text]) proving to be superior to miltefosine.

Indexed as

AnimalsAntiprotozoal AgentsCell LineCell SurvivalInhibitory Concentration 50Leishmania mexicanaMacrophagesMiceMolecular StructureParasitic Sensitivity TestsPhosphorylcholineQuinazolinonesAntiprotozoal AgentsmiltefosinePhosphorylcholineQuinazolinonesLeishmania mexicanaPhthalic anhydridesQuinazolin-2,4-dioneRAW 264.7 macrophage

Identifiers

PMID27531196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.