ArticleBiology letters2016
Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations.
Article in Biology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 34 citations in OpenAlex.
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo).Scientific reports · 2024Article
- Importance of Genetic-Fitness Correlations for the Conservation of Amphibians.Animals : an open access journal from MDPI · 2023Review
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Habitat fragmentation in the Brazilian Atlantic Forest is associated with erosion of frog immunogenetic diversity and increased fungal infections.Immunogenetics · 2022Article
- Spatiotemporal adaptive evolution of an MHC immune gene in a frog-fungus disease system.Heredity · 2021Article
- Divergence between genes but limited allelic polymorphism in two MHC class II A genes in Leach's storm-petrels Oceanodroma leucorhoa.Immunogenetics · 2019Article
- Ancestral chytrid pathogen remains hypervirulent following its long coevolution with amphibian hosts.Proceedings. Biological sciences · 2019Article
- Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations.Immunogenetics · 2019Article
- A cold-blooded view of adaptive immunity.Nature reviews. Immunology · 2018Review
- Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions.Frontiers in immunology · 2018Review
- Major histocompatibility complex variation and the evolution of resistance to amphibian chytridiomycosis.Immunogenetics · 2017Review
- Characterization of MHC class IA in the endangered southern corroboree frog.Immunogenetics · 2017Article
- Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations.Biology letters · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogen-driven selection can favour major histocompatibility complex (MHC) alleles that confer immunological resistance to specific diseases. However, strong directional selection should deplete genetic variation necessary for robust immune function in the absence of balancing selection or challenges presented by other pathogens. We examined selection dynamics at one MHC class II (MHC-II) locus across Panamanian populations of the túngara frog, Physalaemus pustulosus, infected by the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd). We compared MHC-II diversity in highland túngara frog populations, where amphibian communities have experienced declines owing to Bd, with those in the lowland region that have shown no evidence of decline. Highland region frogs had MHC variants that confer resistance to Bd. Variant fixation appeared to occur by directional selection rather than inbreeding, as overall genetic variation persisted in populations. In Bd-infected lowland sites, however, selective advantage may accrue to individuals with only one Bd-resistance allele, which were more frequent. Environmental conditions in lowlands should be less favourable for Bd infection, which may reduce selection for specific Bd resistance in hosts. Our results suggest that MHC selection dynamics fluctuate in túngara frog populations as a function of the favourability of habitat to pathogen spread and the vulnerability of hosts to infection.
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