ArticleBMC veterinary research2016
Iron-regulated gene ireA in avian pathogenic Escherichia coli participates in adhesion and stress-resistance.
Article in BMC veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Identification of Virulence Genes Associated with Pathogenicity of TranslocatingMicroorganisms · 2024Article
- Distribution of virulence-associated genes, antibiotic resistance and phylogenetic groups in Escherichia coli isolated from domestic and racing pigeons.Veterinary research communications · 2023Article
- Association Between UropathogenicInfection and drug resistance · 2023Article
- Adaptive strategies of uropathogenic Escherichia coli CFT073: from growth in lab media to virulence during host cell adhesion.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Comparative Pathogenomics ofInfection and immunity · 2021Article
- Avian PathogenicPathogens (Basel, Switzerland) · 2021Review
- Deletion of theFrontiers in veterinary science · 2021Article
- Article
- Role of LsrR in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli.Poultry science · 2020Article
- Identification of ireA, 0007, 0008, and 2235 as TonB-dependent receptors in the avian pathogenic Escherichia coli strain DE205B.Veterinary research · 2020Article
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9 authors.
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Abstract
backgroundAvian pathogenic Escherichia coli (APEC) causes avian colibacillosis, which results in economic and welfare costs in the poultry industry worldwide. The pathogenesis of avian pathogenic E. coli strains is not well defined. Here, the function of an outer membrane protein encoded by the ireA gene of avian pathogenic E. coli strain DE205B was investigated.
resultsThe ireA gene was distributed in 32.9 % (46/140) of tested E. coli strains, with high percentages in the phylogenetic ECOR groups B2 (58.8 %, 10/17) and D (55.9 %, 19/34). The gene expression level of ireA of APEC strain DE205B in high Fe M9 media was 1.8 times higher (P < 0.05) than that in low Fe M9 media. An ireA deletion mutant and complementary strain were constructed. Compared with the wild-type strain DE205B, the expression of most ferric uptake genes in the ireA deletion mutant were significantly upregulated (P < 0.05). The adhesion ability of the ireA deletion mutant to DF-1 cells was significantly decreased. The survival rate of ireA deletion mutant was reduced 21.17 % (P < 0.01), 25.42 (P < 0.05) and 70.0 % (P < 0.01) under alkali, high osmolarity, and low temperature (4 °C) conditions, respectively, compared with the wild-type strain.
conclusionsThe results suggested that the protein encoded by the iron-regulated gene ireA has roles in adhesion and stress resistance in avian pathogenic E. coli.
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