ArticleInternational journal of obesity (2005)2016
Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- The influence of early life exposures on the infant gut virome.Gut microbes · 2025Article
- Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring.Journal of neurochemistry · 2025Review
- Alterations in Gut Microbiota of Infants Born to Mothers with Obesity.Biomedicines · 2025Article
- Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring.European heart journal · 2024Review
- Sex-Dependent Variations in Hypothalamic Fatty Acid Profile and Neuropeptides in Offspring Exposed to Maternal Obesity and High-Fat Diet.Nutrients · 2024Article
- TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice.Brain sciences · 2022Article
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
- Differential analysis of the bacterial community in colostrum samples from women with gestational diabetes mellitus and obesity.Scientific reports · 2021Article
- Maternal metabolic health drives mesenchymal stem cell metabolism and infant fat mass at birth.JCI insight · 2021Article
- Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities.Frontiers in physiology · 2021Review
- Developmental programming of mitochondrial biology: a conceptual framework and review.Proceedings. Biological sciences · 2020Review
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Mitochondrial inefficiency in infants born to overweight African-American mothers.International journal of obesity (2005) · 2018Observational
- Obesity and asthma.The Journal of allergy and clinical immunology · 2018Review
- Maternal high-fat diet associated with altered gene expression, DNA methylation, and obesity risk in mouse offspring.PloS one · 2018Article
- The effect of obesity, weight gain, and weight loss on asthma inception and control.Current opinion in allergy and clinical immunology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesMaternal obesity increases risk for childhood obesity, but molecular mechanisms are not well understood. We hypothesized that primary umbilical vein endothelial cells (HUVEC) from infants of overweight and obese mothers would harbor transcriptional patterns reflecting offspring obesity risk. SUBJECTS/
methodsIn this observational cohort study, we recruited 13 lean (pre-pregnancy body mass index (BMI) <25.0 kg m
resultsA total of 142 transcripts were differentially expressed in HUVEC from infants of overweight-obese mothers (false discovery rate, FDR<0.05). Pathway analysis revealed that genes involved in mitochondrial and lipid metabolism were negatively correlated with maternal BMI (FDR<0.05). To test whether these transcriptomic patterns were associated with distinct nutrient exposures in the setting of maternal obesity, we analyzed the cord blood lipidome and noted significant increases in the levels of total free fatty acids (lean: 95.5±37.1 μg ml
conclusionsPrenatal exposure to maternal obesity alters HUVEC expression of genes involved in mitochondrial and lipid metabolism, potentially reflecting developmentally programmed differences in oxidative and lipid metabolism.
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