ArticleJournal of global antimicrobial resistance2016
Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.
Article in Journal of global antimicrobial resistance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A cloaked glutamate decarboxylase sustains the GABA shunt inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic epidemiology of theFrontiers in microbiology · 2026Article
- Genomic Sequencing Profiles ofTropical medicine and infectious disease · 2023Article
- Distribution and origins ofMicrobial genomics · 2023Article
- First Detection of Mycobacterium tuberculosis Clinical Isolates Harboring I491F Borderline ResistanceAntimicrobial agents and chemotherapy · 2022Article
- Distribution ofTropical medicine and infectious disease · 2022Article
- Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.Emerging infectious diseases · 2021Article
- Computational modeling and bioinformatic analyses of functional mutations in drug target genes inComputational and structural biotechnology journal · 2021Article
- Geno-Spatial Distribution of Mycobacterium Tuberculosis and Drug Resistance Profiles in Myanmar-Thai Border Area.Tropical medicine and infectious disease · 2020Article
- Dispersal ofFrontiers in microbiology · 2019Article
- Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.PloS one · 2019Article
- Characterization of the most commonInfection and drug resistance · 2019Article
- Draft Genome Sequences of Two Drug-Resistant Mycobacterium tuberculosis Isolates from Myanmar.Genome announcements · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Drug-resistant tuberculosis (TB) is a major health threat in Myanmar. An initial study was conducted to explore the potential utility of whole-genome sequencing (WGS) for the diagnosis and management of drug-resistant TB in Myanmar. Fourteen multidrug-resistant Mycobacterium tuberculosis isolates were sequenced. Known resistance genes for a total of nine antibiotics commonly used in the treatment of drug-susceptible and multidrug-resistant TB (MDR-TB) in Myanmar were interrogated through WGS. All 14 isolates were MDR-TB, consistent with the results of phenotypic drug susceptibility testing (DST), and the Beijing lineage predominated. Based on the results of WGS, 9 of the 14 isolates were potentially resistant to at least one of the drugs used in the standard MDR-TB regimen but for which phenotypic DST is not conducted in Myanmar. This study highlights a need for the introduction of second-line DST as part of routine TB diagnosis in Myanmar as well as new classes of TB drugs to construct effective regimens.
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Registered trials
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