ArticleBMC medicine2016
Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance.
Article in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Reporting practices for genomic epidemiology of tuberculosis: a systematic review of the literature using STROME-ID guidelines as a benchmark.The Lancet. Microbe · 2021Pooled it
- Genomic variations in Mycobacterium tuberculosis from the lungs and blood of HIV-infected individuals in Uganda: insights into compartmentalization.African health sciences · 2024Article
- A comparison of phenotypic and WGS drug susceptibility testing inJAC-antimicrobial resistance · 2023Article
- Origin and Global Expansion ofGenes · 2022Article
- Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action ofAntimicrobial agents and chemotherapy · 2020Article
- Cloning and Protein Expression ofBioResearch open access · 2020Article
- Molecular and genomic typing for tuberculosis surveillance: A survey study in 26 European countries.PloS one · 2019Article
- Alternate splicing of transcripts upon Mycobacterium tuberculosis infection impacts the expression of functional protein domains.IUBMB life · 2018Article
- SINGLE NUCLEOTIDE POLYMORPHISM OFAfrican journal of infectious diseases · 2018Article
- Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial.BMC medicine · 2017Article
- Twenty years and counting: epidemiology of an outbreak of isoniazid-resistant tuberculosis in England and Wales, 1995 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Comparative Genomic Analysis of Two Clonally Related Multidrug ResistantFrontiers in cellular and infection microbiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe largest outbreak of isoniazid-resistant (INH-R) Mycobacterium tuberculosis in Western Europe is centred in North London, with over 400 cases diagnosed since 1995. In the current study, we evaluated the genetic variation in a subset of clinical samples from the outbreak with the hypothesis that these isolates have unique biological characteristics that have served to prolong the outbreak.
methodsFitness assays, mutation rate estimation, and whole-genome sequencing were performed to test for selective advantage and compensatory mutations.
resultsThis detailed analysis of the genetic variation of these INH-R samples suggests that this outbreak consists of successful, closely related, circulating strains with heterogeneous resistance profiles and little or no associated fitness cost or impact on their mutation rate.
conclusionsSpecific deletions and SNPs could be a peculiar feature of these INH-R M. tuberculosis isolates, and could potentially explain their persistence over the years.
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