Evidence map›Paper›PMID 27530702›Full record

ArticleScientific reports2016

ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat.

Justin D Crane, Samuel A Yellin, Frank J Ong, Nina P Singh, Norman Konyer, Michael D Noseworthy, Louis A Schmidt, Saroj Saigal, Katherine M Morrison

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  8. Metabolic implications of pancreatic fat accumulation.Nature reviews. Endocrinology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Justin D CraneDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Samuel A YellinDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Frank J OngDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Nina P SinghDepartment of Radiology, McMaster University Medical Center, Hamilton, ON, Canada.
Norman KonyerImaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada.
Michael D NoseworthyDepartment of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada.
Louis A SchmidtDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
Saroj SaigalDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Katherine M MorrisonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
McMaster University · CAMcMaster University Medical Centre · CASt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Premature birth in conjunction with extremely low birth weight (<1 kg, ELBW) is associated with insulin resistance and increased cardiometabolic health risk compared to birth at full term with normal birth weight (NBW). However, little is known regarding the biologic mediators of these effects. Abdominal and ectopic lipid accumulation is linked to insulin resistance and metabolic dysfunction, yet whether ELBW survivors are predisposed to aberrant lipid deposition in adulthood is unknown. We used magnetic resonance imaging in a cohort of 16 NBW and 29 ELBW participants to determine if ELBW survivors have differences in pancreatic, hepatic, subcutaneous and visceral fat distribution compared to NBW participants. ELBW individuals had a higher proportion of liver and pancreatic fat compared to NBW subjects (P < 0.05). Abdominal subcutaneous fat, but not visceral fat, area was higher in ELBW survivors compared to NBW individuals. In multivariate analyses, tissue fat measures were most highly related to BMI and sex, but not preterm birth. This work highlights that fat deposition is enhanced in adults born preterm and suggests that ectopic fat accretion driven by their relatively greater adiposity may contribute to the higher rates of metabolic dysfunction seen in ELBW survivors.

Indexed as

SurvivorsAdipose TissueAdultFemaleHumansInfant, Extremely Low Birth WeightInfant, NewbornLiverMagnetic Resonance ImagingMalePancreasSubcutaneous Fat

Identifiers

PMID27530702
PMCPMC4987614
OpenAlexW2517972865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.