ArticleNeurocritical care2017
Elevated Red Cell Distribution Width is Associated with Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage.
Article in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Red blood cell distribution width as a predictor of mortality and poor functional outcome after acute ischemic stroke: a meta-analysis and meta-regression.BMC neurology · 2024Pooled it
- Associations between C-reactive protein and white blood cell count, occurrence of delayed cerebral ischemia and poor outcome following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.Acta neurologica Belgica · 2021Pooled it
- Baseline Red Blood Cell Distribution Width as a Predictor of Stroke Occurrence and Outcome: A Comprehensive Meta-Analysis of 31 Studies.Frontiers in neurology · 2019Pooled it
- Correlation between red blood cell distribution width and deep vein thrombosis in patients with lower limb fractures.Frontiers in cardiovascular medicine · 2026Article
- Red Blood Cell Distribution Width May Predict Drug-Induced Anemia and Prognosis in Patients Affected by Primary/Secondary Myelofibrosis Treated with Ruxolitinib.Oncology and therapy · 2025Article
- The role of red cell distribution width in predicting 7-day in-hospital mortality in patients with acute ischemic stroke.Northern clinics of Istanbul · 2025Article
- Association between mean corpuscular volume and 3 month outcome in patients with acute ischemic stroke: a second analysis based on a prospective cohort study.Frontiers in neurology · 2025Article
- Interrelationships Between Inflammatory Score, Delayed Cerebral Ischemia and Unfavorable Outcome in Patients with aSAH: A Four-Way Decomposition.Journal of inflammation research · 2024Article
- Association between red blood cell distribution width and the prognosis of brain death in patients with a Glasgow Coma Scale < 6.Scientific reports · 2023Article
- Red-cell distribution width as a prognostic marker for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis.World neurosurgery: X · 2023Review
- Is there any relationship between red blood cell distribution width and prognosis of brain death?Caspian journal of internal medicine · 2023Article
- Relationship between platelet indices and red cell distribution width and short-term mortality in traumatic brain injury with 30-day mortality.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Association between hemoglobin-to-red blood cell distribution width ratio and hospital mortality in patients with non-traumatic subarachnoid hemorrhage.Frontiers in neurology · 2023Article
- The predictive values of admission characteristics for 28-day all-cause mortality in septic patients with diabetes mellitus: a study from the MIMIC database.Frontiers in endocrinology · 2023Article
- Association of RDW, NLR, and PLR with Atrial Fibrillation in Critical Care Patients: A Retrospective Study Based on Propensity Score Matching.Disease markers · 2022Article
- Postoperative red blood cell distribution width predicts functional outcome in aneurysmal subarachnoid hemorrhage after surgical clipping: A single-center retrospective study.Frontiers in neurology · 2022Article
- Association Between Red Cell Distribution Width and Hospital Mortality in Patients with Sepsis.The Journal of international medical research · 2021Observational
- Risk Factors for Acute Coronary Syndrome in Upper Gastrointestinal Bleeding Patients.Gastroenterology research and practice · 2021Article
- Initial red cell distribution width as a predictor of poor neurological outcomes in out-of-hospital cardiac arrest survivors in a prospective, multicenter observational study (the KoCARC study).Scientific reports · 2020Observational
- Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke.Aging · 2020Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated red blood cell distribution width (RDW) has been associated with thrombotic disorders including myocardial infarction, venous thromboembolism, and ischemic stroke, independent of other inflammatory and coagulation biomarkers. The purpose of this study was to determine whether elevated RDW is associated with cerebral infarction and poor outcome after aneurysmal subarachnoid hemorrhage (aSAH).
methodsIn this retrospective single-center cohort of aSAH patients (October 2009-September 2014), elevated RDW was defined as a mean RDW >14.5 % during the first 14 days after aSAH. Outcomes included cerebral infarction (CI) by any mechanism and poor functional outcome, defined as discharge modified Rankin Scale (mRS) >4, indicating severe disability or death.
resultsOf 179 patients, 27 % had a high Hunt-Hess grade (IV-V), and 76 % were women. Twenty-four patients (13.4 %) underwent red blood cell (RBC) transfusion and compared to patients with normal RDW, patients with an elevated RDW were at greater odds of RBC transfusion (OR 2.56 [95 % CI, 1.07-6.11], p = 0.035). In univariate analysis, more patients with elevated RDW experienced CI (30.8 vs. 13.7 %, p = 0.017). In the multivariable model, elevated RDW was significantly associated with CI (OR 3.08 [95 % CI, 1.30-7.32], p = 0.011), independent of known confounders including but not limited to age, sex, race, high Hunt-Hess grade, and RBC transfusion. In multivariable analysis, RDW elevation was also associated with poor functional outcome (mRS > 4) at discharge (OR 2.59 [95 % CI, 1.04-629], p = 0.040).
conclusionsRDW elevation is associated with cerebral infarction and poor outcome after aSAH. Further evaluation of this association is warranted as it may shed light on mechanistic relations between anemia, inflammation, and thrombosis after aSAH.
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