ArticleImmunologic research2017
Clinicopathologic correlation of 282 leukocytoclastic vasculitis cases in a tertiary hospital: a focus on direct immunofluorescence findings at the blood vessel wall.
Article in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 27 citations in OpenAlex.
- Clinical and Direct Immunofluorescence Correlates of Systemic Involvement in Leukocytoclastic Vasculitis.The Australasian journal of dermatology · 2026Article
- More Than Just Mosquito Bites: A Travel-Associated Case of Cutaneous Small-Vessel Vasculitis.Cureus · 2025Article
- Japanese Spotted Fever with Severe Myositis: A Diagnostic Challenge.Internal medicine (Tokyo, Japan) · 2025Article
- High detection rate for perivascular deposits of immunoglobulins in immune complex vasculitis from biopsies of early macular lesions.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
- Discovery and Characterization of Intercondylar Transphyseal Complexes and their Oncological Significance in Transphyseal Extension of Pediatric Osteosarcoma.Orthopaedic surgery · 2022Article
- Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond.JID innovations : skin science from molecules to population health · 2021Review
- Diagnosis and management of leukocytoclastic vasculitis.Internal and emergency medicine · 2021Review
- Biomarkers and Pathogenic Mechanisms in Autoimmunity.Immunologic research · 2017Article
- Update on vasculitis: an overview and dermatological clues for clinical and histopathological diagnosis - part I.Anais brasileiros de dermatologiaReview
- Systemic disease in leukocytoclastic vasculitis: a focus on direct immunofluorescence findings.Anais brasileiros de dermatologiaArticle
- Update on vasculitis: overview and relevant dermatological aspects for the clinical and histopathological diagnosis - Part II.Anais brasileiros de dermatologiaReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is the largest direct immunofluorescence (DIF) analysis of patients with histology-proven cutaneous leukocytoclastic vasculitis (LCV). To establish the correlation of deposition of immune complexes at the blood vessel walls with underlying causes and prognosis of LCV, we performed a retrospective study from January 2007 to December 2014. The patients are followed at the Department of Dermatology, Hospital Das Clínicas da Faculdade de Medicina da Universidade de São Paulo, a tertiary hospital at São Paulo, Brazil. We reviewed the data of 282 biopsy-proven LCV cases with DIF performed. For the statistical analysis, we included only patients with positive DIF exclusively in vessel walls (235/282 patients). We planned to find a correlation between the DIF profiles of LCV patients and the epidemiology data, underlying causes and prognosis. Ages ranged from five to 87 years old (yo), median age of 45 and 191/282 (67.73 %) were female individuals. DIF analysis showed positivity in 70.21 % of the samples, and C3 was the most frequent immunoreactant. Immunoglobulin A (IgA) deposition at the blood vessel wall was related to age and absence of autoimmune/inflammatory diseases. Immunoglobulin M (IgM) deposition at the blood vessel wall was related to females, autoimmune/inflammatory disorders, C3 and C4 consumption and antinuclear antibody and anti-SSA/anti-SSB positivity. Immunoglobulin G (IgG) deposition at the blood vessel wall was associated with age and positive ANCA; finally, C3 deposition at the blood vessel wall was associated with hematuria and renal involvement. Systemic involvement was present in 12.5 % cases of LCV patients. C3 deposits, the most frequent finding of this study, were related to renal involvement; IgA deposits to absence of autoimmune or inflammatory diseases; IgM deposition to the presence of autoimmune or inflammatory diseases and IgG deposits were associated with positive ANCA. DIF seems to be an important method to establish the prognosis and underlying etiology of LCV. Characterization of the immune complex at the blood vessel wall by DIF is relevant to determine underlying conditions related to LCV.
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