Evidence map›Paper›PMID 27530601›Full record

ArticleJournal of neurointerventional surgery2017

Acute Recanalization of Thrombo-Embolic Ischemic Stroke with pREset (ARTESp): the impact of occlusion time on clinical outcome of directly admitted and transferred patients.

Sascha Prothmann, Benedikt J Schwaiger, Alexandra S Gersing, Wolfgang Reith, Thomas Niederstadt, Alexandra Felber, Wiebke Kurre

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Journal of neurointerventional surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02437409 (Acute Recanalization of Thrombo-Embolic Ischemic Stroke With pREset), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02437409 completednot on this map

Acute Recanalization of Thrombo-Embolic Ischemic Stroke With pREset (ARTESp)

TypeobservationalSponsorPhenox GmbHRan2013 to 2015Enrolled115ConditionsStrokeArmspREset thrombectomy retriever
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. The initial experience with the Embotrap III stent-retriever in a real world setting.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
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  10. Acute ischemic stroke treatment model for Poland in the mechanical thrombectomy era - which way to go?Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022
    Review
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sascha ProthmannAbteilung für Diagnostische und Interventionelle Neuroradiologie, Klinikum rechts der Isar, Technische Universität München, München, Germany.ORCID http://orcid.org/0000-0002-3964-3885
Benedikt J SchwaigerAbteilung für Diagnostische und Interventionelle Neuroradiologie, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Alexandra S GersingAbteilung für Diagnostische und Interventionelle Neuroradiologie, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Wolfgang ReithKlinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
Thomas NiederstadtInstitut für Klinische Radiologie, Universitätsklinikum Münster, Münster, Germany.
Alexandra FelberInstitut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Ev. Stift St. Martin, Gemeinschaftsklinikum Mittelrhein, Koblenz, Germany.
Wiebke KurreNeuroradiologische Klinik, Klinikum Stuttgart, Stuttgart, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAcute Recanalization of Thrombo-Embolic Ischemic Stroke with pREset (ARTESp) is a prospective multicenter study assessing the efficacy and safety of the pREset stent retriever for the treatment of intracranial vessel occlusion. Determination of the effect of transfer status on clinical outcome was a secondary objective.

methodsEfficacy was measured by recanalization success (Thrombolysis in Cerebral Infarction score ≥2b) and favorable clinical outcome at 90 days (modified Rankin Scale 0-2). Intracranial hemorrhage (ICH) and death at 90 days were safety measures. The outcome of directly admitted (DAP) and transferred (TP) patients was investigated using multivariable regression models.

resultsFour study centers included 100 patients (mean age 68.3 years, median National Institutes of Health Stroke Scale score 15). Recanalization success was achieved in 84.4% after a mean of 1.7 passes. ICH was detected in 14.0%, with 2.0% being symptomatic. At 90 days, 62.5% of the patients had a favorable outcome and 7.3% died. TP had longer occlusion times (289 vs 180 minutes, p<0.001) and a lower rate of favorable outcome (58.0% vs 78.4%, p=0.046) than DAP. Multivariable regression revealed occlusion time as the critical determinant (OR=0.963, 95% CI 0.931 to 0.997, p=0.032), whereas transfer status itself showed no significant association (OR=0.565, CI 0.133 to 2.393, p=0.438).

conclusionspREset proved to be safe and effective for the treatment of acute intracranial vessel occlusion. Increased occlusion time impaired clinical outcome in TP. TRIAL REGISTRATION NUMBER: NCT02437409; Results.

Indexed as

AgedAged, 80 and overBrain IschemiaFemaleHumansMaleMechanical ThrombolysisMiddle AgedPatient AdmissionPatient TransferProspective StudiesStentsStrokeThromboembolismTime FactorsTreatment OutcomeDeviceStrokeThrombectomy

Identifiers

PMID27530601
PMCPMC5574392

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.