ArticleAmerican journal of epidemiology2016
Diverse Cumulative Impact of Chronic Diseases on Physical Health-Related Quality of Life: Implications for a Measure of Multimorbidity.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Pooled it
- Measuring multimorbidity beyond counting diseases: systematic review of community and population studies and guide to index choice.BMJ (Clinical research ed.) · 2020Pooled it
- A Genome-Wide Association Study of Premenstrual Symptoms in Two Nordic Populations.Biological psychiatry global open science · 2026Article
- Evaluating the impacts of critical time intervention implementation on health service utilization among homeless-experienced veterans: a retrospective observational study.BMC health services research · 2026Observational
- Validating ICD code case definitions for condition case ascertainment in multimorbidity measurement: a retrospective chart review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The association between multimorbidity and arteriovenous fistula creation outcomes.Journal of vascular surgery · 2026Article
- Quality of life among women of reproductive age during the accumulation of multiple chronic conditions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Associations between ischaemic stroke subtypes and physical functioning in the first year post-stroke: a patient-reported outcome study.Journal of patient-reported outcomes · 2026Article
- Pilot study on the use of a multimorbidity index in patients receiving home parenteral nutrition.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Bio-Inspired Artificial Intelligence Multimorbidity Score for Human-Machine Clinical Risk Stratification.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Sociodemographic predictors of health-related quality of life dimensions in hypertensive patients: A cross-sectional study in a Ghanaian Municipal Hospital.PLOS global public health · 2026Article
- Multimorbidity measurement strategies for predicting hospital visits.BMC health services research · 2025Article
- Comorbidities and comorbidity burden in patients with neurocognitive disorders: findings from the MEMORA Cohort Study.European geriatric medicine · 2025Article
- Prevalence, incidence, risk factors and economic burden in multimorbidity among adult Indians: the MILAN cohort study protocol.BMJ open · 2025Article
- Longitudinal Trajectories of Multimorbidity and Psychosocial Resilience Resources in Midlife and Older Adults: Findings From the Health and Retirement Study.Journal of aging and health · 2025Article
- Premenstrual Disorders and Quality of Life in Sweden.JAMA network open · 2025Article
- Association between comorbidity indices and nursing home admission in patients with Alzheimer's disease: a longitudinal observational study using the MEMORA cohort.BMC geriatrics · 2025Observational
- Capturing the care of complex community-based health center patients: A comparison of multimorbidity indices and clinical classification software.Health services research · 2025Article
- Development of Multimorbidity Indexes Based on Common Mental Health Conditions.International journal of public health · 2025Article
- Higher than expected telemedicine use by racial and ethnic minority and cognitively impaired Medicare beneficiaries.Health affairs scholar · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Debate continues on how to measure and weight diseases in multimorbidity. We quantified the association of a broad range of chronic diseases with physical health-related qualify of life and used these weights to develop and validate a multimorbidity weighted index (MWI). Community-dwelling adults in 3 national, prospective studies-the Nurses' Health Study (n = 121,701), Nurses' Health Study II (n = 116,686), and Health Professionals Follow-up Study (n = 51,529)-reported physician-diagnosed diseases and completed the Short Form 36 physical functioning (PF) scale over multiple survey cycles between 1992 and 2008. Mixed models were used to obtain regression coefficients for the impact of 98 morbid conditions on PF. The MWI was formed by weighting conditions by these coefficients and was validated through bootstrapping. The final sample included 612,592 observations from 216,890 participants (PF mean score = 46.5 (standard deviation, 11)). The association between diseases and PF varied severalfold (median, -1.4; range, -10.6 to 0.8). End-stage organ diseases were associated with the greatest reduction in PF. The mean MWI score was 4.8 (median, 3.7; range, 0-53), and the mean number of comorbid conditions was 3.3 (median, 2.8; range, 0-34). This validated MWI weights diseases by severity using PF, a patient-centered outcome. These results suggest that simple disease count is unlikely to capture the full impact of multimorbidity on health-related quality of life, and that the MWI is feasible and readily implemented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.