Evidence map›Paper›PMID 27530266›Full record

ReviewNature reviews. Urology2016

Overactive bladder in children.

Israel Franco

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 38 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 7 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05709990 nacompletednot on this mapstarted 2023, after this paper: background citation

Efficacy and Safety of High Dose Vitamin D Supplementation for Overactive Bladder Dry in Children: A Randomized Clinical Trial

TypeinterventionalSponsorXing LiuRan2023 to 2023Enrolled303ConditionsOveractive BladderArmsSolifenacin Succinate 5 MG Oral Tablet [Vesicare], Vitamin D3, Standard urotherapy
NCT05989646 narecruitingnot on this mapstarted 2021, after this paper: background citation

Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children, and Modulation of Brain Activity by Transcutaneous Electrical Nerve Stimulation - a Functional Magnetic Resonance Imaging Study

TypeinterventionalSponsorAalborg University HospitalRan2021 to 2027Enrolled65ConditionsUrinary Incontinence, Daytime Wetting, Urination Disorders, Urination InvoluntaryArmsSacral TENS
NCT07535619 recruitingnot on this mapstarted 2022, after this paper: background citation

The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children and Adolescents - the PpUF-study.

TypeobservationalSponsorAalborg University HospitalRan2022 to 2028Enrolled110ConditionsUrinary Incontinence, Daytime Wetting, Urination Disorders, Urologic Diseases
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  20. Giggle incontinence: a scoping review.Pediatric research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Israel FrancoYale New Haven Hospital, Children's Bladder and Continence Program, 789 Howard Avenue, FMP 300, PO Box 208058, New Haven, Connecticut 06520-8058, USA.
Yale New Haven Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overactive bladder (OAB) is a ubiquitous syndrome that is defined by urinary urgency with, or without urinary incontinence. OAB is observed in all parts of the world, with a prevalence of 5-12% in children (5-10 years of age) and a prevalence of 0.5% in older adolescents (16-18 years of age). Published data indicate that around a third of children with OAB are likely to become adults with similar complaints. Studies in children and in adults with OAB indicate that these individuals are more likely to also have anxiety, depression and attention deficit problems, and that appropriate treatment of these comorbidities can often improve the patient's OAB symptoms. Furthermore, data from twin studies and familial surveys seem to indicate a genetic component of OAB. Pharmacological treatments of OAB in children have improved in the past 5 years, moving beyond anticholinergic agents and including the off-label use of α-blockers, β3-agonists and intravesical botulinum toxin. Use of several different electrical stimulation techniques is also effective, both as first-line treatments, and for patients with treatment-refractory symptoms. Overall the outlook of children with OAB seems to be improving, with a greater understanding of the pathophysiology of this syndrome. Treatment modalities that target the source of the underlying problem, especially in children, are likely to provide the best patient outcomes.

Indexed as

Adrenergic alpha-AntagonistsChildCholinergic AntagonistsHumansUrinary Bladder, OveractiveUrinary IncontinenceAdrenergic alpha-AntagonistsCholinergic Antagonists

Identifiers

PMID27530266
OpenAlexW2509600170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.